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  Item type:Publication, Access status: Metadata only ,

  Effect of Home-Based Regular Exercise Training Program in Females with Asthma: A Randomized Controlled Trial

  (Elsevier BV, 2024-01-01)

  Ayse Sena Manzak Dursun

  ;

  Semiramis Ozyilmaz

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  Pinar Atagun Guney

  ;

  Aysegul Yabaci Tak

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  DURSUN, AYŞE ESRA

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  Item type:Publication, Access status: Metadata only ,

  Cover, Volume 41, Issue 8

  (Wiley, 2020-07-27)

  Ceren Tunca

  ;

  Tuncay Şeker

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  Fulya Akçimen

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  Cemre Coşkun

  ;

  Elif Bayraktar

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  Item type:Publication, Access status: Metadata only ,

  Calcific Tendonitis

  (Springer Berlin Heidelberg, 2023-01-01)

  Emre Bilgin

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  Mehmet Kapicioglu

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  Kerem Bilsel

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  KAPICIOĞLU, MEHMET

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  BİLSEL, İSMAIL KEREM

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  Item type:Publication, Access status: Metadata only ,

  #4052 immunosuppressive treatment results in patients with primary iga nephropathy in turkiye: A nationwide study

  (Oxford University Press (OUP), 2023-06-01)

  Aysegul Oruc

  ;

  Abdullah Sumnu

  ;

  Aydin Turkmen

  ;

  Taner Basturk

  ;

  Egemen Cebeci

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  Abstract Background and Aims IgA nephropathy (IgAN) is the most common cause of primary glomerulonephritis in Turkey, as well as all over the world. Along with the frequent occurrence, deleterious renal outcome odds make treatment approaches important. Additionally, for high-risk individuals immunosuppressive treatment (IST) is recommended. However, studies to date revealed conflicting results regarding IST. Therefore, we aimed to investigate IST results among IgAN patients which is the leading primary glomerulonephritis in Turkiye. Method The data of 1656 IgAN patients in the Primary Glomerular Diseases Study of the Turkish Society of Nephrology Glomerular Diseases Study Group (TSN-GOLD) were analyzed. A total of 506 primary IgAN patients (63.4% male, mean age 38.9±12.5 years) were included and divided into two groups according to treatment protocols as isolated corticosteroid (69.6%) and combined IST (30.4%) groups. The median follow-up duration was 24 (3-218) months. Results Remission (66.6% partial remission, 33.4% complete remission) was achieved in 70.6% of patients. Systolic and diastolic blood pressures, urea, creatinine, and proteinuria levels were lower, and eGFR levels were higher in responsive patients (Table 1). There was no difference between the treatment groups in terms of remission rates (p = 0.147) and remission types’ rates (p = 0.279). Remission rates were different between treatment subgroups. However, there was no difference between the treatment subgroups according to the remission types (p = 0.132) (Table 2). Complete remission was lower in the S1 and T1 categories (p = 0.003 and 0.039, respectively). The serious infection was higher in the combined IST group (17.1% vs 2.9%). The outcome data of 229 individuals was evaluated, 40 of 229 (17.5%) developed ESRD and 8 were dead. In the multivariate analysis, eGFR (OR 1.007, 95%CI 1.001-1.013, p = 0.020), proteinuria (OR 1.000, p = 0.009), MEST-C S1 (OR 1.912, 95%CI 1.216-3.005, p = 0.005), MEST-C T2 (OR 0.226, 95%CI 0.102-0.501, p = < 0.001) were found to be significant regarding remission. Conclusion IST provides remission in high-risk IgAN patients but was associated with serious adverse events. The fact that the remission rates were similar between the treatment groups and that the complete remission rate was low in chronic changes supports the necessity of determining the treatment choice according to patient characteristics.

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  Item type:Publication, Access status: Open Access ,

  Antioxidative barrier indicators of pre-school children in case of active dental caries

  (Research Square Platform LLC, 2023-04-07)

  Sinem Yildirim

  ;

  jose miguel amenabar

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  Meltem Bakkal

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  BAKKAL, MELTEM

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  Abstract Background: Antioxidant system is a powerful defense system of the body works against damages caused by free radicals. The present study investigated the effect of active dental caries on oxidative stress by evaluating the antioxidative stress indicators in saliva and serum samples of children. Methods: Thirty eight children aged between 35-72 months were participated in this study. Unstimulated whole saliva and serum samples were collected from the children before and after the performance of their dental treatments. Salivary; pH, flow rate and total protein concentrations were measured. Total antioxidant status (TAS) and Total oxidant status (TOS) levels of serum and saliva samples were determined. In addition, saliva and serum levels of Nitric oxide (NO), Catalase (CAT) and Glutathione peroxidase (GPx) were measured quantitatively. Results: According to the quantitative measurements, TAS showed an increase in the post-treatment saliva/serum samples, whereas TOS had a decrease. In addition, NO and CAT levels of pre-treatment saliva/serum samples were higher than the levels found in post-treatment samples. It was also found that the concentrations of GPx increased statistically after treatment. The positive correlations of these parameters were found between whole saliva and serum samples, except the GPx levels. Conclusions: Saliva is has a great potential in biomedical research, as well as serum and it constitutes a defence, against free radical-modified oxidative stress due to active dental caries. The oxidative/antioxidative balance appeared to shift toward the antioxidant status after the children became caries-free.

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