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  Evaluating incidental findings in cervical mri scans: The prevalence and clinical relevance of incidental findings

  (Galenos Yayinevi, 2025-01-17)

  Nevin Köremezli Keskin

  ;

  Mehmet Denizhan Yurtluk

  ;

  Merve Başdemirci

  ;

  Onur Başdemirci

  ;

  Abdullah Emren Taçyıldız

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  Objective: This study aims to examine the frequency, types, and clinical significance of incidental findings in cervical magnetic resonance imaging (MRI) scans and their implications for patient care. Materials and Methods: A total of 331 cervical MRI scans were reviewed retrospectively at Karabük University Research and Teaching Hospital between April 2022 and April 2023. Patients presenting with arm and neck pain or symptoms suggesting abnormalities of the cervical spine were included; those whose images were affected by artifacts were excluded. Incidental findings were recorded and categorized according to their type, location, and potential clinical significance. Results: Our cohort consisted of 221 female patients (69%) and 101 male patients (31%), amounting to a total of 322 patient records. Loss of cervical lordosis (71%) and cervical disc herniation (92%) were the most prevalent findings in the cervical spine. Additional findings included syringomyelia, cerebellar tonsillar herniation, and empty sella. After being diagnosed with thyroid cancer, one patient received appropriate care. The distribution of incidental findings by gender was not statistically significant. This study highlights the frequency and variety of incidental findings in cervical MRI scans, along with their possible clinical significance. The findings are consistent with earlier studies, highlighting the necessity of carefully analyzing these results to detect potentially fatal disorders. Conclusion: It is crucial not to overlook incidental abnormalities in cervical MRI scans for the early identification of clinically relevant disorders. Future research should concentrate on creating uniform protocols for handling incidental results to successfully balance clinical benefits and resource consumption.

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  Item type:Publication, Access status: Open Access ,

  Antioxidative barrier indicators of pre-school children in case of active dental caries

  (Research Square Platform LLC, 2023-04-07)

  Sinem Yildirim

  ;

  jose miguel amenabar

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  Meltem Bakkal

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  BAKKAL, MELTEM

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  Abstract Background: Antioxidant system is a powerful defense system of the body works against damages caused by free radicals. The present study investigated the effect of active dental caries on oxidative stress by evaluating the antioxidative stress indicators in saliva and serum samples of children. Methods: Thirty eight children aged between 35-72 months were participated in this study. Unstimulated whole saliva and serum samples were collected from the children before and after the performance of their dental treatments. Salivary; pH, flow rate and total protein concentrations were measured. Total antioxidant status (TAS) and Total oxidant status (TOS) levels of serum and saliva samples were determined. In addition, saliva and serum levels of Nitric oxide (NO), Catalase (CAT) and Glutathione peroxidase (GPx) were measured quantitatively. Results: According to the quantitative measurements, TAS showed an increase in the post-treatment saliva/serum samples, whereas TOS had a decrease. In addition, NO and CAT levels of pre-treatment saliva/serum samples were higher than the levels found in post-treatment samples. It was also found that the concentrations of GPx increased statistically after treatment. The positive correlations of these parameters were found between whole saliva and serum samples, except the GPx levels. Conclusions: Saliva is has a great potential in biomedical research, as well as serum and it constitutes a defence, against free radical-modified oxidative stress due to active dental caries. The oxidative/antioxidative balance appeared to shift toward the antioxidant status after the children became caries-free.

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  Item type:Publication, Access status: Metadata only ,

  Knowledge Level and Attitudes of Physiotherapy Students on Tissue/Organ Transplantation and Donation: A Cross-sectional Survey

  (Nova Southeastern University, 2024-03-22)

  Deniz Tuncer

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  Hulya Nilgun Gurses

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  TUNCER, DENİZ

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  GÜRSES, HÜLYA NILGÜN

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  Purpose: Physiotherapists do not have the opportunity to acquire sufficient knowledge and skills in tissue/organ donation and transplantation as part of their education. The aim was to examine the level of knowledge and attitudes of physiotherapy students regarding organ donation and transplantation. Method: The study was designed as a descriptive cross-sectional study and conducted among the four academic years of physiotherapy students. A total of 161 students participated in this study. The level of knowledge and attitudes were assessed using the ‘Organ-Tissue Donation and Transplantation Knowledge Scale’ and the ‘Organ Donation Attitude Scale’ along with the sociodemographic information form. Results: Overall score of the ‘Organ-Tissue Donation and Transplantation Knowledge Scale’ was 13.04 ± 2.51, which corresponds to a good level of knowledge. The mean scores of students' attitudes toward organ donation measured by the ‘Organ Donation Attitude Scale’ were 99.26±13.44 for the ‘humanity and moral conviction’, 22.29±7.98 for the ‘fear of medical neglect’, and 29.34±9.65 for the ‘fear of bodily mutilation’ subdimensions, corresponding to a high level of attitude. A significant majority of students (90.1%, n=145) knew the definition of brain death. Conclusions: The role of healthcare professionals in informing and directing patients and their relatives about organ donation is important in increasing the awareness and positive attitudes about organ donation. Well-structured educational programs can enhance the role of physiotherapists to promote public organ donation knowledge and attitude. Efforts should be made to provide physiotherapists with comprehensive and appropriate training on organ donation and transplantation.

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  Item type:Publication, Access status: Open Access ,

  A review of ergogenic nutritional supplements for athletes

  (Peertechz Publications Private Limited, 2023-10-04)

  Gunes-Bayir Ayşe

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  Çemberci İpek Melek

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  GÜNEŞ BAYIR, AYŞE

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  Ergogenic supplements are defined as substances that contribute to or support the doing or production of a job. These supplements are used for many purposes such as increasing the performance of athletes, accelerating recovery in athletes, improving capacity, and reducing and preventing muscle injuries and muscle fatigue. Ergogenic supplements, which are of great interest to athletes and trainers, are classified as nutritional aids, pharmacological aids, psychological aids, mechanical and biomechanical aids, and physiological aids. Among these supplements, they are the most actively used nutritional aids and attract attention in the market as muscle-building nutritional supplements, weight-reducing nutritional supplements, performance-enhancing nutritional supplements, and general health-promoting nutritional supplements. Protein and amino acids provide benefits in long-term or short-term explosive power activities. Fats are used as the main fuel in long-term aerobic exercises. In addition, caffeine, ginseng, antioxidants, and coenzyme Q10 also serve as ergogenic nutritional supplements. It has been reported in studies that minerals such as B, C and E vitamins, chromium, magnesium, iron, and zinc affect sports performance in a good way. In case of deficiency of the aforementioned vitamins and minerals in athletes, many negativities occur. In this study, the use of ergogenic nutritional supplements by athletes before, during, and after training was compiled using the current literature on the types of these supplements.

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  Item type:Publication, Access status: Open Access ,

  Familial Atypical Hemolytic Uremic Syndrome with Positive pS1191L (c.3572C> T) Mutation in CFH A Single-Center Experience

  (Springer Science and Business Media LLC, 2019-08-15)

  Fadime ERSOY DURSUN

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  Gözde YESIL

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  Hasan DURSUN

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  Gülşah SASAK

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  YEŞİL, GÖZDE

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  Abstract Background: Atypical hemolytic uremic syndrome is a condition characterized by thrombocytopenia, microangiopathic hemolytic anemia, and acute kidney injury, which can exhibit a poor prognosis. Gene mutations play a key role in this disease, which may be sporadic or familial. Methods: We studied, 13 people from the same family were investigated retrospectively for gene mutations of familial atypical hemolytic uremic syndrome after a patient presented to our emergency clinic with atypical hemolytic uremic syndrome and reported a family history of chronic renal failure. Results: The pS1191L mutation in the complement factor H gene was heterozygous in 6 people from the family of the patient with atypical hemolytic uremic syndrome. One of these people was our patient with acute renal failure and the other two are followed up by the Nephrology Clinic due to chronic renal failure. The other 3 persons showed no evidence of renal failure. The index case had a history of 6 sibling deaths; two of them died of chronic renal failure. Plasmapheresis and fresh frozen plasma treatment was given to our patient. When patient showed no response to this treatment, eculizumab therapy was started. Conclusions: The study demonstrated that a thorough family history should be taken in patients with atypical hemolytic uremic syndrome. These patients may have familial type of the disease and they should be screened genetically. Eculizumab should be the first choice in the treatment with plasmapheresis. It should be kept in mind that the use of eculizumab as prophylaxis in post-transplant therapy is extremely important for prevention of rejection.

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