Welcome to the Bezmialem Academic Repository

Bezmialem Vakıf University's Institutional Academic Archive System aims to ensure that the scientific knowledge and research outputs produced by our university are made available openly and sustainably for the benefit of society and all stakeholders. Our university considers it a fundamental responsibility to contribute to the advancement of science and the dissemination of academic knowledge, in line with the principles of transparency and reliability. Within the system, various academic outputs, such as articles, theses, books, book chapters, reports, and presentations, are made accessible.

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16863

Publications

2551

Sustainable Development Goals

725

Theses


1167

Persons

1176

Projects

111

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Recent Submissions

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Design and Synthesis of New Thienopyrimidine Derivatives as Potential Anticancer Agents: From Cytotoxicity Screening to VEGFR Inhibition Modeling
(2026-02-01) Tokalı F. S.; Şenol H.; Ateşoğlu Ş.; Çakır F.; Tokalı P.; Akbaş F.
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Novel triazole-urea hybrids as promising EGFR inhibitors: Synthesis, molecular modeling and antiproliferative activity studies against breast cancer
(2025-12-15) TÜRE A.; Gülcan M. M.; DİNGİŞ BİRGÜL S. İ.; Erdoğan O.; Erdoğan Ö.; ÖZ TUNCAY F.; Çakmak Ü.; KOLCUOĞLU Y.; Cevik O.; Akdemir A.; et al.
Breast cancer is the second leading cause of mortality among women globally. In this study, novel promising urea derivatives containing a 4-phenyl-5-sulphanylidene-4,5-dihydro-1H-1,2,4-triazole group were synthesized and evaluated for their biological activities against breast cancer. The cytotoxicity and apoptotic profiles of these compounds were assessed on the MCF7 breast cancer cell line and the L929 fibroblast cell line. Compound 5c exhibited the strongest anticancer activity against MCF7 cells with an IC50 value of 56.97±4.22 µM, while it showed significantly lower cytotoxicity against L929 cells (IC50 = 1651±18.39 µM). Compound 5c also induced early apoptosis in MCF7 cells, with an apoptosis rate of 18.40% and 5.28%, respectively. Additionally, the EGFR inhibitory activities of the synthesized compounds were evaluated, with compound 5i demonstrating the most potent EGFR inhibition, showing an IC50 value of 35.1 nM. These results suggest that compound 5c likely exerts its anticancer effects through mechanisms other than EGFR inhibition, while compound 5i has significant potential as an effective EGFR inhibitor. Molecular modeling studies were conducted to suggest putative binding interactions of compounds 5d, 5e and 5i with wildtype hEGFR. Further studies are warranted to explore their activity against other cancer types.
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ADHD, social skills and risky internet use among elementary school children
(2025-12-01) DERİN S.; Celik S.; Selman S. B.
Background: Previous studies have established a link between Attention-Deficit/Hyperactivity Disorder (ADHD) and risky internet use (RIU); however, the processes underlying this association remain unclear. This study examines whether a proportion of the association between ADHD and RIU was shared with social skills. Methods: The sample included 142 children aged 6–12 years (65% female, M = 8.5, SD = 1.7), comprising 71 children diagnosed with ADHD and 71 controls without ADHD. Standardized assessments were administered to measure RIU and social skills. Path analysis was employed to evaluate the association among ADHD, social skills, and RIU. Key demographic variables, including gender, birth timing, age of speech onset, household income, parental education, and number of siblings, were controlled for in the analyses. Results: An ADHD diagnosis was significantly associated with reduced social skills (β = − 1.68, p < 0.001), and reduced social skills was strongly linked to higher levels of RIU (β = − 0.57, p = 0.004). The direct association between ADHD and RIU was not statistically significant (β = − 0.52, p = 0.169). However, a significant indirect effect was observed, indicating that ADHD-RIU link was shared with reduced social skills (β = 0.96, p = 0.004). Conclusions: The findings indicate that a significant proportion of the association between ADHD and RIU was shared with social skills, emphasizing the importance of social skills as a potential factor for RIU risk in children with ADHD. Interventions that focus on enhancing social skills may support efforts to address RIU in this population.