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Bezmialem Vakıf University's Institutional Academic Archive System aims to ensure that the scientific knowledge and research outputs produced by our university are made available openly and sustainably for the benefit of society and all stakeholders. Our university considers it a fundamental responsibility to contribute to the advancement of science and the dissemination of academic knowledge, in line with the principles of transparency and reliability. Within the system, various academic outputs, such as articles, theses, books, book chapters, reports, and presentations, are made accessible.


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    Item type:Publication, Access status: Open Access ,
    Analysis of serum boron, arsenic and aluminium in Hashimoto’s Thyroiditis: A pilot study
    (2026-01-01)
    PASTACI ÖZSOBACI N.
    ;
    KARIŞ D.
    ;
    ERDEM M. G.
    ;
    ATEŞ F.
    Hashimoto’s thyroiditis (HT) is a common autoimmune disease with its unclear pathogenesis. HT, widely diagnosed in women, targets thyroid gland and its parenchyma. Thyroid gland is damaged by pro-inflammatory cytokines and mediators due to an imbalanced immune system. Trace elements play vital roles in many physiological and pathological inflammatory process. Dysfunctions of reactive oxygen species production and anti-oxidant protective systems in HT effect alterations of trace/toxic element levels. The biological, anti-inflammatory and anti-oxidant effects of boron (B) on endocrine system have been pointed out in several studies. Arsenic (As) and aluminium (Al), as environmental toxic elements, induce oxidative stress and inflammation also including thyroid gland. The present pilot study was aimed to evaluate alterations of serum B, As and Al in patients with HT. The individuals were categorized in two groups; patients with HT (HT Group, n=30) and healthy controls (HC Group, n=30). Serum element levels were measured using ICP-OES. Serum B and As levels in HT Group were significantly higher than HC Group (p 0.001 and p 0.05; respectively). There was a significant positive correlation between serum As-Al levels in HT Group. The present study revealed that higher serum B levels in HT might present its re-distribution form tissues and the protective effect of B against inflammation due to oxidative stress. Otherwise, higher serum As and Al, and their positive correlation in HT express their hazardous effects on thyroid dysfunction. Further studies should be warranted to determine effects of a variety trace/toxic elements in HT by means of molecular and physiopathological pathways. Monitorization of serum elements should be considered as beneficial biomarkers for thyroid functions.
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    Item type:Publication, Access status: Open Access ,
    Real-world Efficacy and Safety of Trastuzumab Deruxtecan in HER2-positive Metastatic Breast Cancer: A Multicenter Retrospective Study from Türkiye
    (2026-04-01)
    Muğlu H.
    ;
    SÜNGER E.
    ;
    ŞEKER CAN L.
    ;
    Han Ö.
    ;
    Güney B.
    Objective: Trastuzumab deruxtecan (T-DXd) is a novel human epidermal growth factor receptor 2 (HER2)-directed antibody-drug conjugate that has demonstrated significant clinical activity in patients with HER2-positive metastatic breast cancer (mBC) in multiple pivotal trials. However, data regarding its effectiveness and safety in real-world settings, particularly from underrepresented regions such as Türkiye, remain limited. Material and Methods: This retrospective, multicenter observational study included HER2-positive mBC patients [immunohistochemistry (IHC) score of 3+, or IHC score of 2+ with in situ hybridization-positive gene amplification] who received T-DXd after at least one prior line of systemic therapy. Clinical outcomes, including objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), and overall survival (OS), were evaluated. Subgroup and univariate Cox regression analyses were conducted to assess prognostic factors. Adverse events (AEs) were recorded and graded according to the Common Terminology Criteria for AEs version 5.0 (CTCAE v5.0). Results: A total of 39 patients were included. The ORR was 89.7% and the DCR was 100%. Median PFS and median OS were not reached at the time of analysis. In univariate analysis, a better Eastern Cooperative Oncology Group performance status and receipt of T-DXd in earlier treatment lines were associated with improved survival outcomes. AEs were generally manageable; grade ≥3 toxicity occurred in 15.4% of patients. Interstitial lung disease (ILD) was observed in 7.7% of patients, leading to treatment discontinuation in one patient. Conclusion: T-DXd demonstrated high clinical efficacy and manageable toxicity in a real-world cohort of Turkish patients with HER2-positive mBC. These results are consistent with those reported in clinical trials and support the use of T-DXd as an effective treatment option in routine clinical practice. Our findings also highlight the importance of early identification and management of treatment-related AEs, particularly ILD.
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    Item type:Publication, Access status: Open Access ,
    Enhancing nursing students’ preoperative care competence and problem-solving skills through video-assisted case-based learning
    (Elsevier BV, 2026-03-01)
    GÜVEN B.
    ;
    Şahin B.
    ;
    Karapınar M.
    ;
    Baş M.
    ;
    Gürkan Ö.
    Background: Competent nursing care provided the preoperative period is crucial for ensuring patient safety, improving surgical outcomes, and preventing potential complications. Traditional teaching methods in nursing programs may be insufficient for developing this competence. This study aimed to evaluate the effect of video-assisted CBL on nursing students’ perceived preoperative care competence and problem-solving skills. Methods: A quasi-experimental, two-group, pretest–posttest design was used in this study. Seventy-seven nursing students were assigned either to the CBL group (n = 38) or to the lecture-based learning (LBL) group (n = 39). Outcomes pertaining to perceived preoperative nursing care competence and problem-solving ability were assessed in both groups using the Perceived Preoperative Nursing Care Competence Scale for Nursing Students (PPreCCNS) and the Problem Solving Inventory (PSI). Results: In the CBL group, the post-intervention total and subscale scores of the PPreCCNS showed significant improvements compared with baseline. The CBL group demonstrated higher mean scores than the LBL group on all PPreCCNS sub-dimensions except for the communication. Regarding the PSI, no significant change in the total score was observed in the CBL group when compared with either the pre-intervention assessment or the LBL group; however, significant difference emerged only in the approach–avoidance style subscale. Conclusions: To enhance students’ perceived competence in preoperative nursing care, active learning approaches such as CBL may be integrated into undergraduate nursing curricula. Further studies are needed to examine the effectiveness of longer-term CBL using diverse scenarios, as well as other active learning strategies, to better support the development of problem-solving skills.
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    Item type:Publication, Access status: Open Access ,
    Scientific Editorial Quality Assurance System (SCEQAS): Foundational Standard (FS-1.0)
    (Prof. Dr. Hülya Öztürk, 2026)
    Hayrettin Öztürk
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    Item type:Publication, Access status: Open Access ,
    Toplu beslenme sistemlerinde çalışan bireylerin afethazırbulunuşluk düzeylerinin belirlenmesi/ Determining the disaster preparedness levels ofindividuals working in public food systems
    KUŞKU, ALEYNA
    ;
    BAYIR, AYŞE GÜNEŞ
    Afet durumunda, doğru ve zamanında besin desteği sağlanması, afetzedelerin sağlık ve iyileşme süreçlerini doğrudan etkilemektedir. Bu bağlamda da toplu beslenme sistemlerinde çalışan bireylerin afetlere yönelik hazırbulunuşluk düzeylerini değerlendirmek, sadece bireysel hazırlıkların değil, aynı zamanda toplu beslenme sistemlerinin de afet anında verimli bir şekilde işlev görmesi için gereken temel faktörlerin ortaya konması açısından büyük önem taşımaktadır. Bu çalışmanın amacı, toplu beslenme sistemlerinde çalışan bireylerin afet hazırbulunuşluk düzeylerini incelemek ve elde edilen bulguları sosyodemografik faktörler doğrultusunda karşılaştırmalı olarak değerlendirmektir. Araştırma Türkiye, İstanbul'da bir toplu beslenme hizmeti sunan şirket çalışanları ile (n=99) gerçekleştirildi. Araştırmada veriler Afet Hazırbulunuşluk Ölçeği (AHBÖ) ve araştırmacı tarafından oluşturulmuş 9 maddeden oluşan sosyodemografik form toplanmıştır. AHBÖ 13 madde ve 4 alt boyuttan (afet fiziksel koruma, afet planlama, afet uyarı sistemleri) oluşan bir ölçme aracıdır. Çalışmaya katılan bireylerin çoğunluğunun yaş aralığı %29,3 ile 45-54 (n=29)'tir. Çalışmaya katılan bireylerin %53,5'i (n=53) kadın, %46,5'i (n=46) erkektir. Medeni durum açısından %57,6'sı (n=56) evli, %42,4'ü (n=42) bekardır. Katılımcıların %43,4'ü (n=43) 2 veya daha çok çocuk sahibidir. Çalışmaya katılım sağlayan bireylerin eğitim düzeyi yoğunlukla %45,5 (n=45) ile ortaöğretimdir. Ekonomik durum açısından katılımcıların %54,5'inin (n=54) geliri giderine denktir. Katılımcıların %64,6'sı (n=64), daha önce bir afet yaşamış olup, %87,9'u (n=87) daha önce bir afet durumunda gönüllü olarak görev almamıştır. Ayrıca çalışmaya katılanların %68,7'si (n=68), daha önce afetler hakkında eğitim almıştır. Çalışma sonucunda, toplu beslenme sistemlerinde çalışan bireylerin AHBÖ toplam puan ortalaması 34,3±5,46 olarak bulunmuştur. Ölçek alt boyutlarından aldıkları ortalama puanlar afet fiziksel koruma alt boyutu için 12,6±2,33, afet planlama alt boyutu için 7,89±1,82, afet yardım alt boyutu için 8,92±1,35, afet uyarı ve sinyaller alt boyutu için 4,92±1,18 bulunmuştur. Mevcut çalışmaya katılan bireylerin cinsiyet, gelir durumu, daha önce afette gönüllü olarak görev alma durumu ve afet eğitimi almalarına göre toplam AHBÖ ölçek puan ortalamaları istatistiksel olarak anlamlı farklılık göstermiştir (p<0,05). Ancak yaş, medeni durum, çocuk sayısı, eğitim düzeyi ve afet yaşama durumları için toplam AHBÖ ölçek puan ortalamaları arasında anlamlı istatistiksel fark bulunamamıştır (p>0,05). AHBÖ alt boyutları arasında yapılan korelasyon analizinde, tüm alt boyutlar arasında pozitif yönde ve istatistiksel olarak anlamlı ilişkiler olduğu belirlenmiştir (p<0,001). Yapılan araştırmanın sonuçları, toplu beslenme sistemlerinde çalışan bireylerin afet hazırbulunuşluk düzeylerinin ortalamanın üzerinde olduğu görülmektedir. Mevcut çalışma; toplu beslenme sistemlerinde çalışan bireylerin farkındalık düzeylerinin artırılması, eğitim ihtiyaçlarının belirlenmesi ve toplumsal dayanıklılığın güçlendirilmesine yönelik bilimsel öneriler sunmaktadır. Çalışma bulguları toplu beslenme sistemlerinde çalışan bireylerin afet hazırbulunuşluk düzeylerinin geliştirilmesine yönelik eğitim planlamalarının, uygulamaya dayalı öğrenme yaklaşımlarının ve kurumsal destek mekanizmalarının önemini vurgulamaktadır.