Welcome to the Bezmialem Academic Repository

Bezmialem Vakıf University's Institutional Academic Archive System aims to ensure that the scientific knowledge and research outputs produced by our university are made available openly and sustainably for the benefit of society and all stakeholders. Our university considers it a fundamental responsibility to contribute to the advancement of science and the dissemination of academic knowledge, in line with the principles of transparency and reliability. Within the system, various academic outputs, such as articles, theses, books, book chapters, reports, and presentations, are made accessible.

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17038

Publications

2551

Sustainable Development Goals

725

Theses


1173

Persons

1185

Projects

111

Org. Units


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Recent Submissions

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Design and Synthesis of New Thienopyrimidine Derivatives as Potential Anticancer Agents: From Cytotoxicity Screening to VEGFR Inhibition Modeling
(2026-02-01) Tokalı F. S.; Şenol H.; Ateşoğlu Ş.; Çakır F.; Tokalı P.; Akbaş F.
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A non-fatal Crimean-Congo hemorrhagic fever virus infection; The balanced cytokine responses on the outcome of the clinical disease
(2026-02-01) Pirincal A.; Cetin N. S. G.; Sumbul B.; Daskaya H.; Durdu B.; Doymaz M. Z.
Crimean-Congo Hemorrhagic Fever (CCHF) is a neglected tick-borne viral disease with high pathogenicity and mortality in humans. This study reports clinical, virological, and immunological findings of a non-fatal severe CCHF case with tick-bite history and active melena. Laboratory results showed thrombocytopenia, elevated liver enzymes (AST, ALT), and prolonged aPTT. During the first four days of illness and recovery phase, viral RNA load, anti-CCHFV IgG/IgM levels, and cytokine profiles were analyzed by RT-qPCR and EIA. This enabled assessment of key immune responses against CCHFV. The patient had a high viral load and was seropositive. A marked increase in IFN-gamma and IL-10 after day two suggests that the immune system was not only fighting the virus, but also modulating inflammation. This immune balance may contribute to recovery by lowering viral load and limiting tissue damage.
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The relationships between frailty and depression, loneliness, and self-neglect in older adults: A cross-sectional study
(2026-02-01) Yasar Y. A.; GENCER S.; Ilhan N.; AŞTI T.
Background and objectives: The growing older adult population in T & uuml;rkiye and the rest of the world highlights the health impacts of psychosocial issues. Frailty-associated with falls, disability, and care needs-often coexists with depression and loneliness. This study investigates how frailty relates to depression, loneliness, and self-neglect in older adults. Methods: This cross-sectional study was conducted at a university hospital in Istanbul. The study was conducted with 259 older adults (>= 65 years) between September 2023 and February 2024. A sociodemographic information form, the Tilburg Frailty Indicator, the Geriatric Depression Scale-15, the Loneliness Scale for the Elderly, the Istanbul Medical School Elder Self-Neglect Questionnaire, and the Barthel Index for Activities of Daily Living were used for data collection. Data were analyzed using descriptive statistics, Pearson\"s correlation analysis, and simple, multiple, and hierarchical multiple linear regression analyses. Results: The prevalence of frailty among the participants was 60.6 %, whereas depressive symptoms were seen in 28.6 %, loneliness was identified in 53.7 %, and self-neglect was detected in 32.4 %. Depression, loneliness, and self-neglect significantly predicted frailty, explaining 51.9 % of its variance (p < 0.001). Furthermore, depression, health perceptions, loneliness, self-neglect, pain, the community where the participants lived the longest, and living with a nuclear family were also significant predictors of frailty. Together, these factors accounted for 65.1 % of the total variance in frailty (p < 0.001). Conclusion: The study found that depression, loneliness, and self-neglect were linked to greater frailty in older adults. Early interventions and psychosocial support may reduce frailty by addressing these issues and promoting social interaction.
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