Welcome to the Bezmialem Academic Repository

Bezmialem Vakıf University's Institutional Academic Archive System aims to ensure that the scientific knowledge and research outputs produced by our university are made available openly and sustainably for the benefit of society and all stakeholders. Our university considers it a fundamental responsibility to contribute to the advancement of science and the dissemination of academic knowledge, in line with the principles of transparency and reliability. Within the system, various academic outputs, such as articles, theses, books, book chapters, reports, and presentations, are made accessible.

Supported by SelenSoft Yazılım

16998

Publications

2551

Sustainable Development Goals

725

Theses


1173

Persons

1179

Projects

111

Org. Units


Pubmed Yayınları

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WoS Yayınları

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Scopus Yayınları

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TRDizin Yayınları

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Recent Submissions

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Design and Synthesis of New Thienopyrimidine Derivatives as Potential Anticancer Agents: From Cytotoxicity Screening to VEGFR Inhibition Modeling
(2026-02-01) Tokalı F. S.; Şenol H.; Ateşoğlu Ş.; Çakır F.; Tokalı P.; Akbaş F.
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A non-fatal Crimean-Congo hemorrhagic fever virus infection; The balanced cytokine responses on the outcome of the clinical disease
(2026-02-01) Pirincal A.; Cetin N. S. G.; Sumbul B.; Daskaya H.; Durdu B.; Doymaz M. Z.
Crimean-Congo Hemorrhagic Fever (CCHF) is a neglected tick-borne viral disease with high pathogenicity and mortality in humans. This study reports clinical, virological, and immunological findings of a non-fatal severe CCHF case with tick-bite history and active melena. Laboratory results showed thrombocytopenia, elevated liver enzymes (AST, ALT), and prolonged aPTT. During the first four days of illness and recovery phase, viral RNA load, anti-CCHFV IgG/IgM levels, and cytokine profiles were analyzed by RT-qPCR and EIA. This enabled assessment of key immune responses against CCHFV. The patient had a high viral load and was seropositive. A marked increase in IFN-gamma and IL-10 after day two suggests that the immune system was not only fighting the virus, but also modulating inflammation. This immune balance may contribute to recovery by lowering viral load and limiting tissue damage.
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