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Bezmialem Vakıf University is committed to contributing to the advancement of science and technology, and to the broad dissemination of knowledge for the benefit of society and all external stakeholders by adopting open, repeatable and reliable research outputs and practices.
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Recent Submissions
Novel triazole-urea hybrids as promising EGFR inhibitors: Synthesis, molecular modeling and antiproliferative activity studies against breast cancer
(2025-12-15) TÜRE A.; Gülcan M. M.; DİNGİŞ BİRGÜL S. İ.; Erdoğan O.; Erdoğan Ö.; ÖZ TUNCAY F.; Çakmak Ü.; KOLCUOĞLU Y.; Cevik O.; Akdemir A.; et al.
Breast cancer is the second leading cause of mortality among women globally. In this study, novel promising urea derivatives containing a 4-phenyl-5-sulphanylidene-4,5-dihydro-1H-1,2,4-triazole group were synthesized and evaluated for their biological activities against breast cancer. The cytotoxicity and apoptotic profiles of these compounds were assessed on the MCF7 breast cancer cell line and the L929 fibroblast cell line. Compound 5c exhibited the strongest anticancer activity against MCF7 cells with an IC50 value of 56.97±4.22 µM, while it showed significantly lower cytotoxicity against L929 cells (IC50 = 1651±18.39 µM). Compound 5c also induced early apoptosis in MCF7 cells, with an apoptosis rate of 18.40% and 5.28%, respectively. Additionally, the EGFR inhibitory activities of the synthesized compounds were evaluated, with compound 5i demonstrating the most potent EGFR inhibition, showing an IC50 value of 35.1 nM. These results suggest that compound 5c likely exerts its anticancer effects through mechanisms other than EGFR inhibition, while compound 5i has significant potential as an effective EGFR inhibitor. Molecular modeling studies were conducted to suggest putative binding interactions of compounds 5d, 5e and 5i with wildtype hEGFR. Further studies are warranted to explore their activity against other cancer types.
Comparison of conventional and modified sling suture techniques in free gingival graft operations-a randomized controlled clinical trial
(2025-12-01) SHAKILIYEVA S.; Sahin D.; GÜNPINAR Ş.; GÜRSEL M.
Background The aim of this study was to investigate the effects of conventional suture (CS) and modified sling suture (MSS) techniques, applied in free gingival graft (FGG) surgery using gingival unit graft (GUT) and conventional graft (CG) techniques, on clinical parameters and graft dimensions. Methods 52 individuals having Cairo Type 2 (RT2) and Type 3 (RT3) gingival recessions in mandibular anterior were divided into four groups as (a) GUT + MSS (n = 13), (b) GUT + CS (n = 13), (c) CG + MSS (n = 13) and (d) CG + CS (n = 13). Keratinized tissue width (KTW), relative gingival recession height (rGRH), and relative vestibule depth (rVD) measurements were recorded using a digital caliper and UNC 15 periodontal probe. Dimensional changes (Delta) of the graft surface area (GSA) was determined by ImageJ software. All measurements were done at baseline, 1st and 3rd months. Results It was determined that the increase in KTW in the 1st and 3rd months in GUT + CS group was significantly higher than GUT + MSS group (p < 0.05). There was no statistically significant difference in Delta rVD and Delta rGRH values between the groups. When Delta GSA (mm2) values were compared between the groups, the decrease in the 1st and 3rd months in the CG + MSS group was found to be significantly higher than the GUT + MSS and GUT + CS groups (p < 0.05). Conclusion Within the limits of this study, it can be concluded that keratinized tissue can be obtained successfully with both GUT or CG techniques in FGG surgery, on the other hand, regardless of the suture technique, GUT showed less graft shrinkage than CG.
Osteoloji
(Güneş Kitabevi, 2025-12-01) Arifoğlu Y.
A cross-sectional study on ChatGPT's alignment with clinical practice guidelines in musculoskeletal rehabilitation
(2025-12-01) SAFRAN E.; YILDIRIM S.
BackgroundAI models like ChatGPT have the potential to support musculoskeletal rehabilitation by providing clinical insights. However, their alignment with evidence-based guidelines needs evaluation before integration into physiotherapy practice.ObjectiveTo evaluate the performance of ChatGPT (GPT-4 model) in generating responses to musculoskeletal rehabilitation queries by comparing its recommendations with evidence-based clinical practice guidelines (CPGs).DesignThis study was designed as a cross-sectional observational study.MethodsTwenty questions covering disease information, assessment, and rehabilitation were developed by two experienced physiotherapists specializing in musculoskeletal disorders. The questions were distributed across three anatomical regions: upper extremity (7 questions), lower extremity (9 questions), and spine (4 questions). ChatGPT\"s responses were obtained and evaluated independently by two raters using a 5-point Likert scale assessing relevance, accuracy, clarity, completeness, and consistency. Weighted kappa values were calculated to assess inter-rater agreement and consistency within each category.ResultsChatGPT\"s responses received the highest average score for clarity (4.85), followed by accuracy (4.62), relevance (4.50), and completeness (4.20). Consistency received the lowest score (3.85). The highest agreement (weighted kappa = 0.90) was observed in the disease information category, whereas rehabilitation displayed relatively lower agreement (weighted kappa = 0.56). Variability in consistency and moderate weighted kappa values in relevance and clarity highlighted areas requiring improvement.ConclusionsThis study demonstrates ChatGPT\"s potential in providing guideline-aligned information in musculoskeletal rehabilitation. However, due to observed limitations in consistency, completeness, and the ability to replicate nuanced clinical reasoning, its use should remain supplementary rather than as a primary decision-making tool. While it performed better in disease information, as evidenced by higher inter-rater agreement and scores, its performance in the rehabilitation category was comparatively lower, highlighting challenges in addressing complex, nuanced therapeutic interventions. This variability in consistency and domain-specific reasoning underscores the need for further refinement to ensure reliability in complex clinical scenarios.Clinical trial numberNot applicable.