Person: MİRİOĞLU, ŞAFAK
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MİRİOĞLU
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ŞAFAK
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- PublicationMetadata onlyA comparison of methods of plasmapheresis for the treatment of late antibody mediated rejection in kidney transplant recipients.(2022-10-06T00:00:00Z) Çalışkan, Yaşar; Mirioglu, Şafak; Dirim, Ahmet Burak; Özluk, Mesude Yasemin; Yeğit, Osman Ozan; Aksoy, Elif; Şafak, Seda; Güller, Nurana; Demir, Erol; Artan, Ayşe Serra; Oto, Özgur Akın; Beşışık, Sevgi; Yazıcı, Halil; Türkmen, Aydın; Lentine, Krista L.; MİRİOĞLU, ŞAFAK
- PublicationMetadata onlyLIMS1 Risk Genotype and T-Cell Mediated Rejection in Kidney Transplant Recipients.(2021-04-28T00:00:00Z) Çalışkan, Yaşar; Karahan, Gonca; Usta Akgül, Sebahat; Mirioğlu, Şafak; Özlük, Mesude Yasemin; Yazıcı, Halil; Demir, Erol; Dirim, Ahmet Burak; Türkmen, Aydın; Edwards, John; Oğuz Savran, Fatma; Sever, Mehmet Şükrü; Kiryluk, Krzysztof; Gharavi, Ali; Lentine, Krista L; MİRİOĞLU, ŞAFAKBackground:This study aims to examine the association of LIM Zinc Finger Domain Containing 1 (LIMS1) genotype with allograft rejection in an independent kidney transplant cohort.Methods:We genotyped 841 kidney transplant recipients for LIMS1 rs893403 variant by Sanger sequencing followed by PCR confirmation of the deletion. Recipients who were homozygous for LIMS1 rs893403 genotype GG were compared to AA/AG genotypes. The primary outcome was T-cell mediated (TCMR) or antibody mediated rejection (ABMR) and secondary outcome was allograft loss.Results:After a median follow-up of 11.4 years, the rate of TCMR was higher in recipients with the GG (n = 200) compared to AA/AG (n = 641) genotypes [25 (12.5%) vs 35 (5.5%); p = 0.001] while ABMR did not differ by genotype [18 (9.0%) vs 62 (9.7%)]. Recipients with GG genotype had 2.4-times higher risk of TCMR than those who did not have this genotype (adjusted hazard ratio (aHR), 1.442.434.12, p = 0.001). A total of 189 (22.5%) recipients lost their allografts during follow up. Kaplan-Meier estimates of 5-year (94.3% vs. 94.4%, p = 0.99) and 10-year graft survival rates (86.9% vs. 83.4%, p = 0.31) did not differ significantly in those with GG compared to AA/AG groups.Conclusions:Our study demonstrates that recipient LIMS1 risk genotype is associated with increased risk of TCMR after kidney transplantation, confirming the role of LIMS1 locus in allograft rejection. These findings may have clinical implications for the prediction and clinical management of kidney transplant rejection by pretransplant genetic testing of recipients and donors for LIMS1 risk genotype.
- PublicationMetadata onlyThe importance of glomerular C3 accumulation in elderly patients with primary membranous nephropathy(2022-05-01T00:00:00Z) Oto, Özgür Akın; Mirioğlu, Şafak; Dirim, Ahmet Burak; Şafak, Seda; Güller, Nurana; Demir, Erol; Artan, Ayşe Serra; Özlük, Mesude Yasemin; Uçar, Ali Rıza; Soltanova, Lala; Nuriyev, Kanan; Yazıcı, Halil; Çalışkan, Yaşar Kerem; MİRİOĞLU, ŞAFAK
- PublicationOpen AccessMiddle-term outcomes in renal transplant recipients with COVID-19: a national, multicenter, controlled study(2022-02-01T00:00:00Z) Oto, Özgür Akın; Öztürk, Savaş; Arıcı, Mustafa; Velioğlu, Arzu; Dursun, Belda; Guller, Nurana; Şahin, İdris; Eser, Zeynep Ebru; Paydaş, Saime; Trabulus, Sinan; Koyuncu, Sumeyra; Uyar, Murathan; Ural, Zeynep; Sadioglu, Rezzan Eren; Dheir, Hamad; Koc, Neriman Sila; Ozer, Hakan; Durak, Beyza Algul; Gul, Cuma Bulent; Kasapoglu, Umut; Oguz, Ebru Gok; Tanrisev, Mehmet; Kuzgun, Gulsah Sasak; Mirioğlu, Şafak; Dervisoglu, Erkan; Erken, Ertugrul; Gorgulu, Numan; Ozkurt, Sultan; Aydin, Zeki; Kurultak, Ilhan; Ogutmen, Melike Betul; Bakirdogen, Serkan; Kaya, Burcu; Karadag, Serhat; Ulu, Memnune Sena; Gungor, Ozkan; Bakir, Elif Ari; Odabas, Ali Riza; Seyahi, Nurhan; Yildiz, Alaattin; Ates, Kenan; MİRİOĞLU, ŞAFAKBackground In this study, we evaluated 3-month clinical outcomes of kidney transplant recipients (KTR) recovering from COVID-19 and compared them with a control group. Method The primary endpoint was death in the third month. Secondary endpoints were ongoing respiratory symptoms, need for home oxygen therapy, rehospitalization for any reason, lower respiratory tract infection, urinary tract infection, biopsy-proven acute rejection, venous/arterial thromboembolic event, cytomegalovirus (CMV) infection/disease and BK viruria/viremia at 3 months. Results A total of 944 KTR from 29 different centers were included in this study (523 patients in the COVID-19 group; 421 patients in the control group). The mean age was 46 +/- 12 years (interquartile range 37-55) and 532 (56.4%) of them were male. Total number of deaths was 8 [7 (1.3%) in COVID-19 group, 1 (0.2%) in control group; P = 0.082]. The proportion of patients with ongoing respiratory symptoms [43 (8.2%) versus 4 (1.0%); P Conclusion The prevalence of ongoing respiratory symptoms increased in the first 3 months post-COVID in KTRs who have recovered from COVID-19, but mortality was not significantly different.
- PublicationMetadata onlyRecurrent and de novo glomerulonephritis following renal transplantation: higher rates of rejection and lower graft survival(2017-12-01T00:00:00Z) Mirioglu, ŞAFAK; Caliskan, Yasar; Goksoy, Yagmur; Gulcicek, Sibel; Ozluk, Yasemin; Sarihan, Irem; Seyahi, Nurhan; KILIÇASLAN, Işın; TÜRKMEN, Aydın; SEVER, Mehmet Şükrü; MİRİOĞLU, ŞAFAKIn this retrospective study with case-control design, we aimed to determine the clinical and pathological characteristics of post-transplant glomerulonephritis (GN), and their effects on transplant recipients.
- PublicationOpen AccessCOVİD-19 infection in a membranous nephropathy patient treated with rituximab.(2020-09-04T00:00:00Z) Elcioglu, Omer Celal; Artan, Ayse Serra; Mirioglu, Safak; Gursu, Meltem; Durdu, Bulent; Koc, Meliha Meric; Okyaltirik, Fatmanur; Gultekin, Mehmet Ali; Kazancioglu, Rümeyza; ELÇİOĞLU, ÖMER CELAL; MİRİOĞLU, ŞAFAK; GÜRSU, MELTEM; DURDU, BÜLENT; MERİÇ KOÇ, MELİHA; OKYALTIRIK, FATMANUR; GÜLTEKİN, MEHMET ALİ; KAZANCIOĞLU, RÜMEYZAWhile COVID-19 pandemic continues to afect our country and most countries in the world, we have to make some changes both in our social life and our approach to healthcare. We have to struggle with the pandemic on one hand and also try to follow up and treat our patients with chronic diseases in the most appropriate way. In this period, one of our group of patients who are challenging us for follow-up and treatment are those who should start or continue to use immunosuppressive therapy. In order to contribute to the accumulation of knowledge in this area, we wanted to report a patient who was followed up with the diagnosis of COVID-19 and had been administered rituximab very recently due to a nephrotic syndrome caused by membranous nephropathy.
- PublicationMetadata onlySerum and urine TNF-like weak inducer of apoptosis, monocyte chemoattractant protein-1 and neutrophil gelatinase-associated lipocalin as biomarkers of disease activity in patients with systemic lupus erythematosus(2020-04-01T00:00:00Z) Mirioglu, ŞAFAK; ÇINAR, Suzan; YAZICI, Hülya; Ozluk, Y.; KILIÇASLAN, Işın; GÜL, Ahmet; Ocal, L.; İNANÇ, Murat; Artim-Esen, B.; MİRİOĞLU, ŞAFAKObjectives
- PublicationMetadata onlyClinical significance of glomerular C3 deposition in primary membranous nephropathy(2021-01-01T00:00:00Z) Oto, Özgür Akın; Demir, Erol; Mirioğlu, Şafak; Dirim, Ahmet Burak; Özlük, Mesude Yasemin; Cebeci, Egemen; Baştürk, Taner; Uçar, Ali Rıza; Soltanova, Lala; Nuriyev, Kanan; Kılıçaslan, Işın; Yazıcı, Halil; Çalışkan, Yaşar Kerem; MİRİOĞLU, ŞAFAKBackground We aimed to investigate the effects of glomerular C3 deposition on clinical, histopathological features, and outcomes of patients with primary membranous nephropathy (MN). Methods A total of 261 patients with biopsy-proven primary MN, who were on follow up for at least 6 months, were included in the study. The patients were grouped according to their C3 immunostaining in kidney biopsy samples at the time of diagnosis: Low intensity [LI; (C3 1 +)] and high intensity [HI; (C3 2 + or C3 3 +)]. The primary outcome was the development of kidney failure. Complete (CR) or partial remission (PR) was defined as secondary outcome. Results Sixteen patients reached the primary outcome after a median follow-up of 33.8 months. Patients in the high intensity group (119 cases) had lower eGFR and higher proteinuria at admission and last follow-up compared to patients in the low intensity group (142 cases). Also, more patients in the high intensity group reached the primary outcome compared to patients in the low intensity group: twelve patients (10.1%) in the high intensity group and four patients (2.8%) in the low intensity group reached the primary outcome (p = 0.015). Kaplan-Meier analysis demonstrated that patients in the high intensity group had a higher risk for kidney failure (p = 0.02). In multivariate logistic regression analysis, high intensity C3 deposition and initial estimated glomerular filtration rate (eGFR) indepenently predicted primary outcome. Conclusion Extensive glomerular C3 deposition is a predictor of kidney failure in patients with MN.
- PublicationMetadata onlyDiffuse Cavernous Hemangioma of the Colon(2016-07-01T00:00:00Z) Mirioglu, ŞAFAK; ÇAVUŞ, Bilger; Iliaz, Raim; Besisik, Fatih; MİRİOĞLU, ŞAFAKA 70-year-old man was admitted to our clinic with a history of rectal bleeding and constipation, his colonoscopy revealed varicosities and bluish nodular lesions of the rectum (Figure 1). Abdominal CT showed multiple nodular lesions beginning from the distal descending colon and extending to the rectum, calcifications suggesting phleboliths were also seen in these lesions. A contrast enhanced pelvic MRI demonstrated multiple tubular lesions showing hyperintensity on T2-weighted images and hypointensity on T1-weighted images, consistent with the affected areas on the CT scan (Figure 2). It was a diffuse cavernous hemangioma, which mostly affects the rectosigmoid colon in the gastrointestinal tract, and can clinically mimic internal hemorrhoids, ulcerative colitis or cancer (1). Gastrointestinal hemangioma is a rare benign vascular neoplasm, and might be associated with a congenital disorder like Osler-Weber-Rendu disease, Maffucci-s syndrome, Klippel-Trenaunay syndrome, or the congenital blue rubber bleb nevus syndrome (2). Even though there are different medical treatment options targeting VEGF and FGF-mediated pathways such as bevacizumab and thalidomide, and endoscopic approaches like sclerotherapy and electrocautery; complete resection of the hemangioma is the only curative treatment method (1, 3). Therefore, the patient was referred to department of surgery for a definitive treatment, and lost to follow-up.
- PublicationMetadata onlyOxidative stress and macrophage infiltration in IgA nephropathy.(2021-11-16T00:00:00Z) Çalışkan, Yaşar; Demir, Erol; Karatay, Ecem; Özlük, Mesude Yasemin; Mirioğlu, Şafak; Dirim, Ahmet Burak; Artan, Ayşe Serra; Usta Akgül, Sebahat; Oto, Özgür Akın; Savran Oğuz, Fatma; Türkmen, Aydın; Lentıne, Krista L.; Yazıcı, Halil; MİRİOĞLU, ŞAFAK