Welcome to the Open Access System!
This site is Bezmialem Vakif University Academic Open Access System. The system was established in June 2019 in order to store the academic outcomes of Bezmialem Vakif University in digital standards and to provide them with open access. OpenAccess includes academic outputs such as articles, presentations, dissertations, books, book chapters and reports produced by Bezmialem Vakif University.
Recent Submissions
Okul çağındaki lösemili çocukların motor yeterlilik düzeyleri akademik katılım düzeyini etkiler mi?
(2024-04-21) Yıldırım K.; Tanrıverdi M.; Şahin S.; Güney Yılmaz G.; Çakır F. B.; YILDIRIM, KARDELEN; TANRIVERDİ, MÜBERRA
Is step-cut shortening osteotomy a better choice than transverse osteotomy for total hip arthroplasty for Crowe type III-IV hip dysplasia?
(2024-01-01) Turgut N.; Erdem M.; ERDEM A. C.; BAYAM L.; Batar S.; Sağlam N.; GÜLABİ D.; ERDEM, AHMET CAN
Introduction: Total hip arthroplasty for developmental hip dysplasia is a challenging surgery due to anatomic abnormalities. Crowe III and Crowe IV hip dysplasia generally necessitates a subtrochanteric shortening osteotomy. Transverse and step-cut osteotomy are the most common procedures for shortening of femur although there is still no consensus which one is a superior method. The objective of this study was to demonstrate whether transverse or step-cut osteotomy is superior in hips who undergo arthroplasty for high riding hip dysplasia. Hypothesis: Our hypothesis was that higher rates of union would be achieved in patients with Crowe III-IV hip dysplasia when the step-cut osteotomy was performed compared to transverse osteotomies. Material and methods: A total of 99 hips from 90 patients (9 bilateral, 81 unilateral; 79 female, 11 male), each with a minimum follow-up duration of two years, were included in this study. The hips were classified as Crowe III (n = 16) or IV (n = 83). All hips were implanted cementless. Transverse or step-cut osteotomy was chosen for osteotomy type. The clinical and functional outcomes were assessed using the Harris Hip Score (HHS), limb length discrepancy (LLD), and limping. The complications and management of these were noted. The union rates were compared between osteotomy types. Results: The mean age at surgery was 48.8 (range, 21–79 years). The follow-up period was 64.3 months in average (range, 24 to 192 months). The mean Harris Hip Score before surgery was 35.6 (range, 18–50), and increased to 88.1 (range, 61–98) points at the most recent follow-up. The preoperative leg length discrepancy (LLD) measured 5.3 cm (with a range of 3 to 6.8), while the postoperative LLD reduced to 0.8 cm (with a range of 0 to 1.6). There were a total of 38 complications in 35 patients out of 99 cases, resulting in a complication rate of 38.4%. The most frequent complication observed was intraoperative femoral fractures, occurring in 13 cases. Residual limping was seen in 73.7% of all. Step-cut osteotomy was performed in 64 hips (35 CDH stem [Zimmer Biomet, Warsaw, IN, USA], 29 Wagner Cone stem [Zimmer Biomet, Warsaw, IN, USA]) and, transverse in 35 hips (22 CDH, 13 Wagner Cone). Six hips had nonunion problem and all of them were operated with a step-cut osteotomy (z-score: –7.12 and p < 0.00001, Mann-Whitney U Test). Conclusion: Transverse osteotomy may be a better option while performing a shortening subtrochanteric level osteotomy for total hip arthroplasty for Crowe III-IV hips. Level of evidence: Level III; observational retrospective cohort study.
Kanserli Çocuklarda Vücut Kompozisyonunun Günlük Yaşam Aktivitelerine Katılımı ile İlişkisi
(2024-04-21) Tanrıverdi M.; Yıldırım K.; Şahin S.; Güney Yılmaz G.; Çakır F. B.; TANRIVERDİ, MÜBERRA; YILDIRIM, KARDELEN
Commentary on: physical activity and exercise for mild cognitive impairment and dementia: a collaborative international guideline.
(2024-04-23) Veronese N.; Soysal P.; Barbagallo M.; Shenkin S. D.; Quinn T. J.; SOYSAL, PINAR
Real-world treatment outcomes from nationwide Onco-colon Turkey registry in RAS wild-type patients treated with biologics second-line mCRC
(2024-04-13) Yildirim M. E.; Karadurmus N.; Okten I. N.; TÜRK H. M.; Urakci Z.; Arslan C.; Celik S.; DANE F.; ŞENDUR M. A. N.; BİLİR C.; et al.; TÜRK, HACI MEHMET
Backgrounds and Objectives Colorectal cancer is one of the leading causes of mortality both globally and in our country. In Turkey, we conducted a multicenter investigation into the effectiveness of second-line treatments and real-life data for patients with RAS wild-type metastatic colorectal cancer (NCT04757311).Materials and Methods In this retrospective analysis, records from 28 centers were collected, and histopathological, molecular, and clinical characteristics were documented. Patients were categorized into groups based on their second-line biological treatments: anti-EGFR (Group A and Group B, panitumumab and cetuximab) and anti-VEGF (Group C, bevacizumab and aflibercept). They were then compared within these groups.Results A total of 588 patients with documented RAS wild-type status were evaluated. The median OS was 15.7, 14.3 and 14.7 months in Group A, Group B and Group C, respectively (p = 0.764). The median PFS of the patients in second-line setting that received panitumumab, cetuximab and bevacizumab/aflibercept were 7.8, 6.6 and 7.4 months, respectively (p = 0.848).Conclusion According to the results of our real-life data study, there is no significant difference in efficiency between the combination of biological agent and chemotherapy used in the second-line treatments.
