Welcome to the Open Access System!
This site is Bezmialem Vakif University Academic Open Access System. The system was established in June 2019 in order to store the academic outcomes of Bezmialem Vakif University in digital standards and to provide them with open access. OpenAccess includes academic outputs such as articles, presentations, dissertations, books, book chapters and reports produced by Bezmialem Vakif University.
Recent Submissions
An in vitro analysis of an innovative standardized phospholipid carrier-based Melissa officinalis L. extract as a potential neuromodulator for emotional distress and related conditions
(2024-01-01) KARA M.; Sahin S.; Rabbani F.; ÖZTAŞ E.; Hasbal-Celikok G.; KANIMDAN E.; KOÇYİĞİT A.; Kanwal A.; Wade U.; Yakunina A.; et al.; KANIMDAN, EBRU; KOÇYİĞİT, ABDÜRRAHİM
Background: Melissa officinalis L. (MO), commonly known as lemon balm, a member of the mint family, is considered a calming herb. In various traditional medicines, it has been utilized to reduce stress and anxiety and promote sleep. A growing body of clinical evidence suggests that MO leaf extract supplementation possesses considerable neuropharmacological properties. However, its possible mechanism of action largely remains unknown. Objective: In the present in vitro studies, we comparatively investigated the central nervous system (CNS)-calming and antioxidative stress properties of an innovative standardized phospholipid carrier-based (Phytosome™) MO extract (Relissa™) vs. an unformulated dry MO extract. Methods: The neuropharmacological effect of the extract was studied in the anti-depressant enzymes γ-aminobutyrate transaminase (GABA-T) and monoamine oxidase A (MAO-A) assays and SH-SY5Y cells brain-derived neurotrophic factor (BDNF) expression assay. The neuroprotective effect of the extract against oxidative stress was assessed in SH-SY5Y cell-based (H2O2-exposed) Total Antioxidant Status (TAS) and Total Reactive Oxygen Species (ROS) assays. The cytotoxic effect of the extract was evaluated using MTT and LDH assays. The extract antioxidant effect was also evaluated in cell-free chemical tests, including TEAC-ABTS, DPPH, Ferric Reducing Antioxidant Power (FRAP), Oxygen Radical Antioxidant Capacity (ORAC), and Hydroxyl Radical Antioxidant Capacity (HORAC) assays. Results: Relissa™ exhibited high GABA-T inhibitory activity, IC50 (mg/mL) = 0.064 vs. unformulated dry MO extract, IC50 (mg/mL) = 0.27. Similar inhibitory effects were also observed for MAO-A. Relissa™ demonstrated an improved neuroprotective antioxidant effect on SH-SY5Y cells against H2O2-induced oxidative stress. Compared to unformulated dry MO extract, Relissa™ exerted high protective effect on H2O2-exposed SH-SY5Y cells, leading to higher cells BDNF expression levels. Moreover, cell-free chemical tests, including TEAC-ABTS, DPPH radical scavenging, FRAP, ORAC, and HORAC assays, validated the improved antioxidant effect of Relissa™ vs. unformulated dry MO extract. Conclusion: The results of the present study support the neuromodulating and neuroprotective properties of Relissa™, and its supplementation may help in the amelioration of emotional distress and related conditions.
Tranexamic Acid and Rhinoplasty: How Do Different Administration Routes Affect Effectiveness?
(2024-03-27) Sezen Göktaş S.; Yenigün A.; Sütcü A. O.; Özturan O.; Tuğrul S.; YENİGÜN, ALPER
THE THYROID FUNCTION IN PATIENTS WITH FIBROMYALGIA SYNDROME
(2024-04-30) Sönmez S.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞE
Although the medical treatment and etiology of fibromyalgia are not fully understood, its effects on patients are considerable. Various symptoms such as chronic pain, fatigue, depression, sleep disturbances, and cognitive issues can significantly impact the quality of life of patients. In this context, the potential relationship between fibromyalgia and nutrition will be explored in this section. Studies examining the role of nutrient supplements in fibromyalgia suggest that dietary changes can reduce fibromyalgia symptoms and alleviate pain, implying potential positive effects. However, it has also been demonstrated that certain dietary components may increase the risk of fibromyalgia or exacerbate symptoms. Particularly, it has been noted that glutamate excitotoxin, a common food additive, may increase central pain sensitivity in individuals. Fibromyalgia is a common condition among rheumatic diseases and shares similarities with autoimmune thyroid diseases, especially hypothyroidism. Therefore, autoimmune thyroid disease, hypothyroidism, and Hashimoto\"s thyroiditis are also discussed in this work. Additionally, studies addressing the relationship between fibromyalgia diagnosis and treatment methods and thyroid diseases, one of the differential diagnoses, are compiled. In conclusion, advanced clinical research is needed to better understand the pathophysiological connection between fibromyalgia syndrome and thyroid diseases. Keywords: Fibromyalgia, Diagnosis and treatment, Nutrition, Autoimmune thyroiditis
Glycopolymeric Photoactive Micelles for Glucose Transporter-Targeted Synergistic Combination Therapy
(2024-03-01) Gençoğlu Katmerlikaya T.; Ersen B. C.; Dağ A.; Sancakli B.; Ozgen P. S. O.; Yalcin E. K.; Avci B.; DAĞ, AYDAN
