Welcome to the Open Access System!


This site is Bezmialem Vakif University Academic Open Access System. The system was established in June 2019 in order to store the academic outcomes of Bezmialem Vakif University in digital standards and to provide them with open access. OpenAccess includes academic outputs such as articles, presentations, dissertations, books, book chapters and reports produced by Bezmialem Vakif University.


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GLUTEN-FREE NUTRITION APPLICATION IN HASHIMOTO’S THYROIDITIS
(2024-05-20) Tayfur B. İ.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞE
The immune system is responsible for protecting and defending our body under normal conditions and helps living things survive by neutralizing factors such as pathogens and infections that threaten the body. However, for some reasons, the body perceives itself as a threat and attacks itself, creating defects. The diseases that occur as a result of this situation are called autoimmune diseases, and if not intervened, they can lead the person from disability to death. Although the underlying causes are not fully understood, an autoimmune disease may also predispose to the formation of another autoimmune disease. However, as a result of research, it is thought that environmental factors together with genetic factors form a whole and cause these diseases. On the other hand, sometimes consumed foods or nutritional components may cause undesirable consequences for individuals. For example, studies have shown that the development of Hashimoto\"s thyroiditis (HT), an autoimmune disease, is supported by a gluten-containing diet. 70-80% genetic factors and 20-30% environmental factors play a role in the progression of this disease. While HT cases have increased rapidly in the last 30 years, the prevalence of the disease increases with age. HT, also known as chronic lymphocytic thyroiditis, is one of the most common autoimmune disorders of the thyroid gland. In the pathogenesis of the disease, there is a close connection with autoantibodies with lymphocytic infiltration along with B and T cells in the thyroid tissue. Chronic fatigue, irritability, unstable mood, as well as stomach, intestinal or cardiovascular problems may be observed in these patients. Additionally, a link has been identified between increased HT and primary thyroid lymphoma and papillary thyroid cancer. Although reported studies suggest that gluten exclusion may be beneficial for some individuals with HT, the diet is very limited, difficult to follow, and carries the risk of nutritional deficiency. In this review, the effect of gluten, a protein found in grains, on some common autoimmune diseases such as Hashimoto\"s thyroiditis has been examined in the light of current scientific publications. Answers were sought to the questions of whether removing gluten from the diet of individuals with autoimmune diseases would benefit the individual or alleviate their clinical symptoms.Keywords: Hashimoto\"s thyroiditis, Gluten-free diet, Autoimmune diseases, Immune system
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Dr. Fatma Saada Emin Kaatcilar, One of the First Female Physicians of the Turkish Republic (1898-1982)
(2023-09-01) YILDIRIM N.; YILDIRIM, NURAN
In the early 20th century, since Istanbul University (Darulfunun) Faculty of Medicine did not accept female students, girls who wanted to study medicine began to go to Europe and America. First, Fatma SaadaEmin and Suad Mahmud Hanim from Izmir were sent to the SwitzerlandGeneva Medical Faculty, with their allocations and education expenses paid by the Aydin Province Special Administration (1915). The following year, the Ministry of Education sent Safiye Ali from Istanbul to the Faculty of Medicine of the University of Wurtzburg in Germany (1916). While they were continuing their education, as a result of the struggle initiated by the girls who wanted to become doctors in Istanbul, Istanbul University\"s Faculty of Medicine started to accept female students (1922). The province of Aydin sent Fatma Saada Emin 20 Ottoman liras every month and also paid 400 Francs as an annual education fee. The First World War ended in 1918, but due to the economic depression caused by the war conditions, this amount could not meet the young student\"s allocation needs. Their allocations were cut off when the Greeks occupied Izmir while the War of Independence was continuing. Fatma Saada Emin and Suad Mahmud Hanim, whose education was in jeopardy, applied to the Ottoman Consulate General in Geneva and expressed their grievances, and their situation was reported to Istanbul. The education expenses of both of them began to be paid from the Istanbul Province budget after 1921. Fatma Saada Emin completed her education, which was prolonged due to war conditions, in 1927 and received a diploma. After completing her specialization in internal medicine, she returned to Izmir. When she received her diploma equivalence certificate, she was appointed to the internal medicine clinic of Izmir Memleket Hospital (1930). Later, she opened a practice in Karsiyaka and started practicing freelance medicine (1932). In the 1943 general elections, she was elected as a member of parliament for the first term and entered the Turkish Grand National Assembly representing Manisa. (1943-1946). When her term as a member of parliament ended, she returned to Izmir and continued to work as a physician in Karsiyaka. Dr. Fatma Saada Emin Kaatcilar did not marry and devoted her life to her patients. She has an important place in the history of Turkish Medicine and women\"s studies, as she is one of the first two female students to go to Europe to study medicine, and in our political history, as the second elected female physician MP. However, no detailed research has been carried out on her so far. In this article, by sharing the information we have compiled from the sources we have access to, Dr. Fatma Saada Emin Kaatcilar is introduced, who served as a health guard for the people of Karsiyaka until her death, and who had the courage to go to a foreign country alone in the turbulent years of WW1, taking on a challenging education such as medicine, in a time when it was not tolerated for girls to even study.
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Sindirim Sistemindeki Mikroorganizmaların Obezite, Hipertansiyon Ve İnsülin Direncine Etkileri
(Gece Kitaplığı, 2024-03-01) Şekerli Z.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞE
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FODMAP ve Bazı Hastalıklarda FODMAP Diyet Uygulamaları
(Özgür Yayınları, 2024-03-01) Semiz D.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞE
Short-chain carbohydrates, called FODMAPs, are fermentable, oligosaccharides, disaccharides, monosaccharides and polyols and are found in most foods. Some individuals may experience gastrointestinal symptoms such as gas, diarrhea, abdominal bloating and cramping when consuming foods containing FODMAPs. In addition, this significantly reduces the quality of life of these individuals and a low FODMAP diet is offered to control these symptoms. The Low FODMAP diet is based on restricting the intake of highly osmotic short-chain carbohydrates that are not slowly absorbed or digested in the human small intestine. On the other hand, Low FODMAP diet planning is implemented in three phases: FODMAP restriction, FODMAP reintroduction and then individualized selective FODMAP according to patients\" tolerance. The Low FODMAP diet has been applied in other functional gastrointestinal disorders, such as irritable bowel syndrome, non-celiac gluten sensitivity, inflammatory bowel diseases, and other functional gastrointestinal disorders. Thus, there is a reduction in symptoms and an increase in the quality of life of individuals with these conditions. However, FODMAP restriction in the diet of individuals also has disadvantages. Since most of the FODMAP components are prebiotic, it may lead to a decrease in fiber intake in the diet and may have negative effects on the intestinal microbiota. A health professional should be involved in the implementation of a low FODMAP diet and follow-up of symptoms. In particular, dietitians should determine the FODMAP components to which the patient is exposed on a daily basis, test food tolerance, check for dietary dependence, provide patient-specific dietary instructions, and ensure maximum dietary diversity by offering alternatives to food sources. This review aims to examine FODMAP carbohydrates, explain the low FODMAP diet, and provide an update on the evidence for the effects of a low FODMAP diet.

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