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Tezler [234]
  • New azolyl-derivatives as multitargeting agents against breast cancer and fungal infections: synthesis, biological evaluation and docking study 

    Carradori, Simone; Maccallini, Cristina; Amoroso, Rosa; Cataldi, Amelia; Fantacuzzi, Marialuigia; Giampietro, Letizia; De Filippis, Barbara; Ammazzalorso, Alessandra; AKDEMİR, ATİLLA; Sisto, Francesca; Gallorini, Marialucia (2021-01-01)
    Nonsteroidal aromatase inhibitors (NSAIs) are well-established drugs for the therapy of breast cancer. However, they display some serious side effects, and their efficacy can be compromised by the development of chemoresistance. ...
  • A NEW PATIENT WITH ANDERMANN SYNDROME: AN UNDERDIAGNOSED CLINICAL GENETICS ENTITY? 

    Degerliyurt, A.; Caglayan, A. O.; Bilguvar, K.; Caglar, CANER; Akgumus, G. (2013-01-01)
    A new patient with Andermann syndrome: an underdiagnosed clinical genetics entity?: Andermann syndrome is an autosomal recessive disorder characterized by the agenesis of the corpus callosum and peripheral neuropathy ...
  • NGLY1 mutation causes neuromotor impairment, intellectual disability, and neuropathy 

    Comu, Sinan; Caglayan, Ahmet Okay; Parman, Yesim; Baranoski, Jacob F.; Gunel, Murat; Bilguvar, Kaya; Yasuno, Katsuhito; Freeze, Hudson H.; Mishra-Gorur, Ketu; Harmanci, Akdes Serin; Erson-Omay, Emine Zeynep; Dolen, Duygu; Caglar, CANER; Akgumus, Gozde Tugce; Kaymakcalan, Hande (2015-01-01)
    N-glycanase 1 (NGLY1) is a conserved enzyme that is responsible for the deglycosylation of misfolded N-glycosylated proteins in the cytoplasm prior to their proteasome-mediated degradation. Disruption of this degradation ...
  • Biallelic Mutations in TMTC3, Encoding a Transmembrane and TPR-Containing Protein, Lead to Cobblestone Lissencephaly 

    Caglar, CANER; Zaki, Maha S.; Silhavy, Jennifer L.; Musaev, Damir; Jerber, Julie; Gleeson, Joseph G.; Gunel, Murat; Abou Jamra, Rami; Ogur, Gonul; Bilguvar, Kaya; Vajsar, Jiri; Caglayan, Ahmet Okay; Almuriekhi, Mariam; Willer, Tobias; Campbell, Kevin P.; Albrecht, Beate; Al-Aama, Jumana Y.; Rosti, Rasim Ozgur; Ben-Omran, Tawfeg; Dikoglu, Esra (2016-11-01)
    Cobblestone lissencephaly (COB) is a severe brain malformation in which overmigration of neurons and glial cells into the arachnoid space results in the formation of cortical dysplasia. COB occurs in a wide range of genetic ...
  • Functional analysis reveals differential effects of glutamate and MCH neuropeptide in MCH neurons 

    Tan, Keith; Azevedo, Estefania; Caglar, CANER; Parolari, Luca; Nectow, Alexander R.; Schneeberger, Marc; Friedman, Jeffrey M.; Domingos, Ana; Li, Zhiying (2018-07-01)
    Objectives: Melanin-concentrating hormone (MCH) neurons in the lateral hypothalamus (LH) regulate food intake and body weight, glucose metabolism and convey the reward value of sucrose. In this report, we set out to establish ...

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