Bezmialem Vakif University DSpace Openaccess Platformu

Welcome to the Open Access System!

This site is Bezmialem Vakif University Academic Open Access System. The system was established in June 2019 in order to store the academic outcomes of Bezmialem Vakif University in digital standards and to provide them with open access. OpenAccess includes academic outputs such as articles, presentations, dissertations, books, book chapters and reports produced by Bezmialem Vakif University.

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Recent Submissions

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Prevalance of Urinary Incontinence and Anal Incontinence: An Internet Based Cross-Sectional Study of Female Turkish University Students

(2023-10-01) GÖKMEN KARASU A. F.; Cetin C.; PASİN Ö.; Karacabay M.; Tanoglu F. B.; Ilhan G.; GÖKMEN KARASU, AYŞE FİLİZ; PASİN, ÖZGE

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KAPOSIFORM HEMANGIOENDOTHELIOMA AND REFRACTORY KASABACH-MERRITT PHENOMENON TREATED WITH SIROLIMUS

(2023-11-01) EREN T.; ÇAKIR F. B.; ÇAKIR, FATMA BETÜL

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Development of a green high-performance liquid chromatography method for tofacitinib quantification in pharmaceutical formulations and degradation studies

(2024-04-02) TIRIS G.; Genc A. A.; ERK N.; TIRIS, GİZEM

A new high-performance liquid chromatography (HPLC) method was applied for the quantification of the active substance of tofacitinib. Analysis was performed on a Chromasil 100 C18 (100.0 x 4.0 mm, 3.5 mu m) stationary phase. The mobile phase consisted of acetonitrile:0.2% phosphoric acid in water (12:88, v/v). The prepared sample (20.0 mu L) was injected into the system. A detection wavelength of 285.0 nm was chosen for the compound, and the flow rate was 0.8 mL/min. The experiment was completed in 5.0 min. The analysis temperature was set to 40.0 degrees C. The method was evaluated using green chemistry. The method was validated according to the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use guidelines. For linearity studies calibration curves were constructed in the range of 10.0-200.0 mu g/mL. The recovery values were calculated at 97.66% and 105.68%. The method developed for the analysis of the active substance had a short analysis time and was cost-effective. It is an environmentally friendly method due to the mobile phase content used. The technique can be used in laboratory analysis and bioequivalence experiments.

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EARTHQUAKE DISASTER AND ITS' ACUTE EFFECT ON PEDIATRIC HEMATOLOGY AND ONCOLOGY.IN TURKIYE; TURKISH PEDIATRIC ONCOLOGY GROUP-TPOG QUESTIONARE STUDY

(2023-11-01) TAÇYILDIZ N.; İNCESOY ÖZDEMİR S.; Kupeli B.; Cemaloglu M.; Acipayam C.; Oncel K.; Akinel A. N.; Karabel N.; Coskun C.; SEZGİN G.; et al.; ÇAKIR, FATMA BETÜL

Publication

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Management preferences of orthopedic surgeons in developmental dysplasia of the hip under 1 year of age in Türkiye: Results of a nationwide cross-sectional survey

(2023-11-01) Cetin B. V.; Bakircioglu S.; Ciftci S.; Soylemez M. S.; Erkus S.; TURHAN Y.; Camurcu I. Y.; Duman S.; Yildirim T.; MEMİŞOĞLU K.; et al.; ŞENARAN, HAKAN

Objective: This study aimed to evaluate the diagnosis and treatment preferences of orthopedic surgeons in developmental dysplasia of the hip (DDH) cases under the age of 1 in Turkiye with a higher incidence of DDH, estimated to be around 5-15 per 1000 live births. Methods: This was a nationwide cross-sectional survey. A link for the online survey, including 16 multiple-choice questions, was sent to the email group of the National Orthopedic Society. Results: Among 233 filled -out surveys, 211 met the inclusion criteria. Half of the participants had experience of 25 DDH cases per year. Over one-third used both anterior and medial approach open reduction, but a trend to anterior open reduction alone was more evident in surgeons treating >50 DDH cases per year. More experienced surgeons were more prone to check the intraoperative reduction with postoperative computed tomography or magnetic resonance imaging. Diagnosis and treatment ages of DDH cases did not significantly change during the coronavirus disease 2019 pandemic. Conclusion: Management preferences of orthopedic surgeons in DDH before walking age primarily depend on the rate of pediatric patients in daily practice and the number of treated DDH cases per year.