Welcome to Open Access System


This site is Bezmialem Vakif University Academic Open Access System. The system was established in June 2019 in order to store the academic outcomes of Bezmialem Vakif University in digital standards and to provide them with open access. OpenAccess includes academic outputs such as articles, presentations, dissertations, books, book chapters and reports produced by Bezmialem Vakif University.


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Recent Submissions

Publication
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Effects of melatonin on both testicular regeneration and recovery of spermatogenesis in busulfan-treated rats
(2022-01-01) Taşlıdere E.; Eşrefoğlu M.; Tok O.; Taşlıdere B.; Bulut H.; EŞREFOĞLU, MUKADDES; TAŞLIDERE, BAHADIR; BULUT, HURI
© 2022, Faculdade de Ciencias Farmaceuticas (Biblioteca). All rights reserved.Testicular damage is one of the most hazardous effects of chemotherapy as it is frequently associated with oligozoospermia and azoospermia. This study aimed at evaluating the protective effect of melatonin in a rat model of busulfan-induced testicular injury. Rats were divided into four groups: control, melatonin, busulfan, busulfan plus melatonin. After 15 days, the semen was collected from the epididymis and testes were assessed. Sperm removed from cauda epididymis and analyzed for sperm count and viability. Testis tissues were also removed, fixed in formalin and were embedded in paraffin. Sections of testis tissue were stained with hematoxylin-eosin for histological examination and prepared for TUNEL (Terminal deoxynucleotide transferase dUTP Nick End Labeling) assay to detect apoptosis and PCNA (proliferating cell nuclear antigenassay) to detect proliferation cells. Serum and testes supernatants were separated to detect testosteron level and oxidative stress parameters. In histological examination, degenerative changes in seminiferous tubules were observed in the experimental groups. In biochemical examination, the total oxidant status (TOS) levels in Busulfan group were significantly higher than in the control group while the total antioxidant status (TAS) levels of all the groups were similar. In conclusion, the beneficial properties of melatonin treatment by its potent anti-oxidants may reduce adverse effects of chemotherapy in the reproductive system in a rodent system.
Publication
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Serum Electrolyte Values and Blood Oxidative Stress Parameters in Patients with Focal and Generalized Epilepsy
(2023-02-01) Sarı G.; Kılıç A.; Uslu F.; Selek Ş.; Üstünova S.; Meral İ.; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; MERAL, İSMAİL
Publication
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Aortic ischemia-reperfusion injury and potency of fluoxetine
(2023-02-01) Altan M.; Yaman M. O.; Kervancığlu G.; Kılıç A.; Kervancıoğlu Demirci E.; Bozdoğan Polat S. H.; Karadeniz Z.; Güner İ.; Yelmen N.; Şahin E. G.; KILIÇ, AYSU

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