Welcome to the Bezmialem Academic Repository
Bezmialem Vakıf University's Institutional Academic Archive System aims to ensure that the scientific knowledge and research outputs produced by our university are made available openly and sustainably for the benefit of society and all stakeholders. Our university considers it a fundamental responsibility to contribute to the advancement of science and the dissemination of academic knowledge, in line with the principles of transparency and reliability. Within the system, various academic outputs, such as articles, theses, books, book chapters, reports, and presentations, are made accessible.
Recent Submissions
The effectiveness of novel remineralising agents in white spot lesion treatment after microabrasion
(2026-12-01) Oglakci Ozkoc B.; Tunc Dicle A.; ALKAN E.; YILMAZ ATALI P.; DALKILIÇ E.; TAĞTEKİN D.
Background: In clinical practice, microabrasion and remineralising agents, or their combinations, could be effective for white spot lesions (WSL) treatment. This study evaluates the effectiveness of four treatments, including two novel remineralising agents, nanohydroxyapatite (nanoHAP) and calcium glycerophosphate (CaGP) in combination with/without microabrasion on WSL. Methods: Artificially created WSL on human enamels were randomly divided into nine groups according to treatments: (1) Group FV/fluoride varnish (Bifluoride 10); (2) Group NanoHAP/nanohydroxyapatite gel (Biodent); (3) Group CaGP/calcium glycerophosphate gel (SPC Kozmetik); (4) Group ICON/resin infiltration (ICON); (5) Group Micro/microabrasion (Opalustre); (6) Group Micro + FV/microabrasion + fluoride varnish; (7) Group Micro + NanoHAP/ microabrasion + nanohydroxyapatite gel; (8) Group Micro + CaGP/microabrasion + calcium-glycerophosphate gel; (9) Group Micro + ICON/microabrasion + resin infiltration. Samples were analysed using a Vickers microhardness (VHN) testing and two fluorescence-based methods (FluoreCam and DIAGNOdent Pen/DDPen) at baseline, after demineralisation and after treatment(n = 10). SEM/EDS was used for the evaluation of surface morphology and elemental analyses (n = 5). The data were statistically analysed (p 0.05). Regarding the presence of microabrasion, no significant differences in VHN, DDPen, FluoreCam, and EDS results were found for NanoHAP- and CaGP-containing groups (p > 0.05). Conclusions: Novel remineralising agents nanoHAP and CaGP could provide promising results with nanoHAP showing superior potential, whereas microabrasion before remineralising agents did not produce a significant additional effect on WSL. Clinical relevance: NanoHAP is an effective alternative to fluoride for treating white spot lesions and may reduce the need for additional microabrasion procedures.
Increased DNA and oxidative damage in PCOS: effect of elevated androgens : Oxidative Damage & Androgens in PCOS
(2026-12-01) Taha H. S.; ATEŞ S.; Arici Halici B. N.; Aktaş S.; Bozali K.; GÜLER E. M.
Purpose: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder involving ovulatory dysfunction, hyperandrogenism, and metabolic disturbances. Systemic inflammation, mitochondrial dysfunction, and elevated oxidative stress have all been asscoiated to androgen excess in PCOS. This study aims to evaluate the impact of hyperandrogenemia on oxidative stress and DNA damage in PCOS patients. Methods: A prospective case–control study was conducted with 178 women between April and November 2022. The cohort included 112 PCOS patients diagnosed per Rotterdam criteria and 66 healthy controls. PCOS patients were divided into hyperandrogenic (HA-PCOS) and non-hyperandrogenic (non-HA PCOS) subgroups. Blood samples were used for the analysis of oxidative stress markers, lipid profiles, hormones, and metabolism. Results: The HA-PCOS group had significantly higher BMI than both non-HA PCOS and control groups (p < 0.05). Despite hormonal differences, metabolic syndrome prevalence did not differ significantly. In compared with controls, oxidative stress, inflammatory, and DNA damage markers were higher in both PCOS categories. Moreover, the HA-PCOS group showed significantly higher levels of oxidative stress markers (TOS, OSI), inflammatory cytokines (TNF-α, IL-6, IL-1β), and DNA damage compared to non-HA PCOS (p < 0.05). Conclusion: DNA damage, persistent inflammation, and elevated oxidative stress are all associated with hyperandrogenism in PCOS. These results highlight how excessive androgen may be linked to oxidative and inflammatory processes. Future research should explore therapeutic interventions targeting oxidative stress and inflammation in PCOS.
Investigation of the relationship between carotid intima-media thickness and angiopoietin-like factor 3 levels in metabolic dysfunction-associated steatotic liver disease
(2026-12-01) Kadioglu Yeniyurt E.; Duran E. N.; Dumur S.; EKİNCİ İ.; Yalcinkaya I.; Ustuner M.; Carpan H. E.; Anataca G.; Akarsu M.; Topal U.; et al.
Metabolic dysfunction–associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a common condition characterized by excessive fat accumulation in the liver and is closely associated with metabolic syndrome (MetS) and insulin resistance. This study aimed to evaluate the relationship between carotid intima-media thickness (CIMT), a marker associated with cardiovascular risk, and circulating levels of angiopoietin-like protein 3 (ANGPTL3) in patients with MAFLD. The study included 88 patients diagnosed with MAFLD and 88 age- and sex-matched healthy controls who visited the internal medicine clinic between August and November 2022. Data on patient characteristics, laboratory values, and associated diseases were taken from the hospital database. Serum ANGPTL3 levels were measured using venous blood samples, and results with p 33.18 predicted MAFLD with 97.8% sensitivity and 83.33% specificity; ANGPTL3 levels > 242 predicted MAFLD with 51.11% sensitivity and 83.33% specificity; and CIMT > 6 (expressed in 0.1 mm units) predicted MAFLD with 83.33% sensitivity and 91.11% specificity. Our study demonstrated increased serum ANGPTL3 levels in patients with MAFLD. Dyslipidemia observed in MAFLD may be mediated through this hepatokine, suggesting that ANGPTL3 could serve as a non-invasive biomarker for MAFLD diagnosis. Furthermore, serum ANGPTL3 may have potential as a biomarker for liver fibrosis assessment in future studies.
Childhood trauma, dissociative experiences and ADHD symptoms in youth
(2026-06-01) DERİN S.; Ergun A. F.; Selman S. B.; Yanik M.
Background: Trauma exposure and dissociative experiences can resemble attention-deficit/hyperactivity disorder (ADHD) symptoms in youth, but it is unclear whether dissociation explains trauma-related attentional symptoms by diagnostic status. Methods: We enrolled 108 youth aged 12-18 years (54 with ADHD; 54 controls) from a child and adolescent psychiatry outpatient service in Türkiye. Youth completed the Childhood Trauma Questionnaire (CTQ) and Adolescent Dissociative Experiences Scale (A-DES); parents completed the Conners Parent Rating Scale-Revised Short Form (CPRS-RS). We estimated a multigroup path model (ADHD vs. control) testing CTQ→A-DES (path a), A-DES→CPRS-RS (path b), and CTQ→CPRS-RS (path c′), with 1000-draw bootstrap confidence intervals, adjusting for sex, internalizing symptoms, socioeconomic status, and number of children in the household. Indirect effects were interpreted as associational. Results: In controls, higher trauma was associated with higher dissociative experiences (a = 0.529, p=.005), and higher dissociative experiences were associated with ADHD-like symptoms (b = 0.292, p<.001). The indirect effect was significant (a × b = 0.155, 95% CI 0.035–0.306; p=.019). In the ADHD group, path a (0.163, p=.153), path b (0.107, p=.230), and the indirect effect (0.017, 95% CI -0.022 to 0.061; p=.380) were not significant. Indirect effects differed between groups (Wald χ²(1)=4.54, p=.033). Conclusions: Dissociative experiences were associated with trauma-related ADHD symptoms in youth without ADHD, but this pathway was not statistically supported in diagnosed ADHD, supporting trauma-informed assessment when attentional complaints arise without confirmed ADHD.