Publication: SIRT1 gene variants are related to risk of childhood obesity
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Date
2015-04-01
Authors
Kilic, Ulkan
GOK, Ozlem
ELIBOL-CAN, BİRSEN
Ozgen, Ilker Tolga
Erenberk, UFUK
Uysal, Omer
DUNDAROZ, Mehmet Rusen
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Abstract
Obesity is a multifactorial disorder resulting from the interaction between genetic, psychological, physical, environmental, and socioeconomic factors. SIRT1 gene has important effects on the regulation of adiponectin, caloric restriction, insulin sensitivity, coronary atherosclerosis, and cardiovascular diseases. The aim of this study was to investigate the association between childhood obesity and SIRT1 gene polymorphisms regarding rs7895833 A > G in the promoter region, rs7069102 C > G in intron 4, and rs2273773 C > T in exon 5 using PCR-CTPP method in 120 obese and 120 normal weight children. In this study, BMI, systolic and diastolic blood pressure, LDL cholesterol, triglyceride, and insulin levels were significantly higher and HDL-cholesterol levels were significantly lower in obese children compared to normal weight children. For rs7895833 A > G, the rate of having AG genotype and G allele was significantly higher in obese children compared to non-obese group (p T. There was no significant difference for rs7069102 C > G gene polymorphism between groups.
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Kilic U., GOK O., ELIBOL-CAN B., Ozgen I. T. , Erenberk U., Uysal O., DUNDAROZ M. R. , -SIRT1 gene variants are related to risk of childhood obesity-, EUROPEAN JOURNAL OF PEDIATRICS, cilt.174, ss.473-479, 2015