Publication: Molecular aspects of circadian pharmacology and relevance for cancer chronotherapy
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Date
2017-10-17
Authors
Authors
ÖZTÜRK, Narin
Ozturk, DİLEK
Kavakli, Ibrahim Halil
OKYAR, Alper
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Abstract
The circadian timing system (CTS) controls various biological functions in mammals
including xenobiotic metabolism and detoxification, immune functions, cell cycle events, apoptosis and
angiogenesis. Although the importance of the CTS is well known in the pharmacology of drugs, it is
less appreciated at the clinical level. Genome-wide studies highlighted that the majority of drug target
genes are controlled by CTS. This suggests that chronotherapeutic approaches should be taken for many
drugs to enhance their effectiveness. Currently chronotherapeutic approaches are successfully applied
in the treatment of different types of cancers. The chronotherapy approach has improved the tolerability
and antitumor efficacy of anticancer drugs both in experimental animals and in cancer patients. Thus,
chronobiological studies have been of importance in determining the most appropriate time of
administration of anticancer agents to minimize their side effects or toxicity and enhance treatment
efficacy, so as to optimize the therapeutic ratio. This review focuses on the underlying mechanisms
of the circadian pharmacology i.e., chronopharmacokinetics and chronopharmacodynamics of
anticancer agents with the molecular aspects, and provides an overview of chronotherapy in cancer
and some of the recent advances in the development of chronopharmaceutics
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Citation
ÖZTÜRK N., Ozturk D., Kavakli I. H. , OKYAR A., -Molecular aspects of circadian pharmacology and relevance for cancer chronotherapy-, International Journal of Molecular Sciences, cilt.18, 2017