Publication: Cancer preventive effects of whole cell type immunization against mice Ehrlich tumors.
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Date
2013-01-01
Authors
AYŞAN, MUSTAFA ERHAN
Authors
Aysan, E
BAYRAK, OF
AYDEMIR, E
TELCI, D
SAHIN, F
YARDIMCI, C
MUSLUMANOGLU, M
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Abstract
Background: Effects of whole cell type immunization on mice Ehrlich tumours were evaluated. Materials
and Methods: After preliminary study, mice were divided two major groups; 1x1000 and 100x1000 live Ehrlich
cell transferred major groups, each divided into four subgroups (n: 10). Study groups were immunized with
Ehrlich cell lysates in 0, 3, 7, 14th days and after 30 days of last immunization, live Ehrlich cells were transferred.
Mice were observed for six months and evaluated for total and cancer free days. Results: Out of 100x1000 cell
transferred solid type study group, all study group mean and tumour free periods were statistically longer than
control groups. All 1x1000 Ehrlich cell transferred study groups survived significantly longer than 100x1000
Ehrlich cell transferred groups. Conclusions: Ehrlich mice tumours were prevented and survival prolonged
with whole cell type immunization. Effects are related to the number of transferred tumor cells.
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Keywords
Cancer
Citation
Aysan E., BAYRAK O., AYDEMIR E., TELCI D., SAHIN F., YARDIMCI C., MUSLUMANOGLU M., -Cancer preventive effects of whole cell type immunization against mice Ehrlich tumors.-, Asian Pacific journal of cancer prevention : APJCP, cilt.14, ss.3515-9, 2013