Publication: Phytochemical screening and evaluation of the antimicrobial and antioxidant activities of Ferula caspica M. Bieb. extracts
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Date
2019-05-01
Authors
Authors
Kahraman, Çiğdem
TOPÇU, GÜLAÇTI
Bedir, Erdal
Tatlı, İrem
Ekizoğlu, M
Akdemir, Zeliha Ş
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Abstract
Chloroform, ethyl acetate and methanol extracts from the aerial parts of Ferula caspica M. Bieb. were
tested for their antioxidant capacities by CUPRAC, ABTS, FRAP, Folin–Ciocalteu and aluminum chloride
methods and for antimicrobial activities by the broth microdilution method. Chloroform and ethyl
acetate extracts showed the highest antioxidant capacity and antimicrobial activity. Three known
sesquiterpene derivatives; 1-(20
,40
-dihydroxyphenyl)-3,7,11-trimethyl-3-vinyl-6(E),10-dodecadien-1-on
e (1), 2,3-dihydro-7-hydroxy-2,3-dimethyl-2-[40
,80
-dimethyl-30
,70
-nonadienyl]-furo[3,2,c]coumarin (2),
2,3-dihydro-7-hydroxy-2,3-dimethyl-3-[40
,80
-dimethyl-30
,70
-nonadienyl]-furo[3,2,c]coumarin(3);
phenylpropanoid; laserine/2-epilaserine (4/5) and steroid mixtures; stigmasterol and b-sitosterol (6/7)
were isolated from chloroform extract; three known flavonoids; kaempferol-3-O-b-glucopyranoside
(8), kaempferol-3-O-a-rhamnopyranoside (9), quercetin-3-O-b-glucopyranoside (10), and one benzoic
acid derivative; 2,4-dihydroxybenzoic acid (11) were isolated from the ethyl acetate extract. The structures were elucidated by spectroscopic methods.
2019 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an
open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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Kahraman Ç., TOPÇU G., Bedir E., Tatlı İ., Ekizoğlu M., Akdemir Z. Ş. , -Phytochemical screening and evaluation of the antimicrobial and antioxidant activities of Ferula caspica M. Bieb. extracts-, SAUDI PHARMACEUTICAL JOURNAL, cilt.27, ss.525-531, 2019