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Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII.

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Date
2015-06-21
Authors
GÜZEL-AKDEMIR, Ö
Akdemir, ATİLLA
KARALı, N
SUPURAN, CT
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Abstract
A series of 2/3/4-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)amino]benzenesulfonamides, obtained from substituted isatins and 2-, 3- or 4-aminobenzenesulfonamide, showed low nanomolar inhibitory activity against the tumor associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII – recently validated antitumor drug targets, being much less effective as inhibitors of the off-target cytosolic isoforms CA I and II.
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tumor
Citation
GÜZEL-AKDEMIR Ö., Akdemir A., KARALı N., SUPURAN C., -Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII.-, Organic & biomolecular chemistry, cilt.13, ss.6493-9, 2015
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