Publication:
Is pentraxin-3 stronger than C-reactive protein to determine inflammation in peritoneal dialysis patients?

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Date
2012-01-01
Authors
Gursu, MELTEM
OZTURK, S.
AYDIN, Z.
KARADAG, S.
DOVENTAS, Y.
KOLDAS, M.
UZUN, S.
SUMNU, A.
KAZANCIOĞLU, RÜMEYZA
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Abstract
Pentraxin-3 (PTX-3) is the prototype of long pentraxins and is produced by many tissues and organs including vascular endothelial cells in response to pro-inflammatory signals. It is thought to be an independent indicator of disease activity. We analyzed the correlation of PTX-3 with other markers of inflammation in peritoneal dialysis (PD) patients. Non-diabetic patients on chronic PD program who meet the dialysis adequacy criteria and who had no active infectious/inflammatory disease were included. Demographic and clinical parameters were recorded as well as hsCRP, fibrinogen, interleukin-6 (IL-6) and PTX-3 levels; and the correlation between them were studied. Twenty-five patients (mean age: 45.7 +/- 12.5 years; female/male ratio: 16/9) were included. Mean PTX-3 level was 2.16 +/- 2.76ng/ml. PTX-3 was found to be correlated positively with only IL-6 among inflammatory markers (r=0.827; p<0.001) but not with hsCRP. With linear regression model, IL-6 was the only independent determinant of PTX-3 levels. PTX-3 may be a more valuable marker of inflammation than CRP in patients on PD.
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dialysis
Citation
Gursu M., OZTURK S., AYDIN Z., KARADAG S., DOVENTAS Y., KOLDAS M., UZUN S., SUMNU A., KAZANCIOĞLU R., -Is pentraxin-3 stronger than C-reactive protein to determine inflammation in peritoneal dialysis patients?-, European Journal of Inflammation, cilt.10, ss.289-295, 2012
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