Publication:
Effects of chitosan on healing and strength of colonic anastomosis in rats

Loading...
Thumbnail Image
Date
2012-10-01
Authors
CITGEZ, B
CENGIZ, AN
AKGUN, I
ULUDAG, M
YETKIN, G
BAHAT, N
OZCAN, O
POLAT, N
Akcakaya, ADEM
KARATEPE, O
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue

Metrics

Search on Google Scholar

Abstract
PURPOSE: To investigate whether chitosan application over colonic anastomosis line, provide reinforcement, and subsequently improve anastomotic healing. METHODS: Forty eight Wistar albino female rats were used and were randomly divided into four groups, 12 rats in each: The control groups (1 and 3) received no further treatment. The experimental groups (2 and 4) received chitosan application over the colonic anastomosis. After sacrifying rats at the end of the experiment (either on day three or on day seven, depending on the group), colonic bursting pressure, a hihydroxyproline level and histopathologic characteristics of the perianastomotic tissue were examined. RESULTS: At three days, chitosan and control groups had similar values for histopathologically. On day seven, chitosan group had significantly higher mean score of collagenization (p=0.007) and a significantly higher bursting pressure (p=0.038). CONCLUSION: Our study emphasizes the positive effect of chitosan in the process of collagenation in colonic anastomosis healing.
Description
Keywords
Gastrointestinal anastomoses
Citation
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001000007
CITGEZ B., CENGIZ A., AKGUN I., ULUDAG M., YETKIN G., BAHAT N., OZCAN O., POLAT N., Akcakaya A., KARATEPE O., -Effects of chitosan on healing and strength of colonic anastomosis in rats.-, Acta cirurgica brasileira, cilt.27, ss.707-12, 2012
Page Views

0

File Downloads

0

Sustainable Development Goals