Publication: Serum endocan levels in women with restless legs syndrome.
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Date
2015-11-19
Authors
CELIK, K
ÇıKRıKÇıOĞLU, MA
HALAC, G
KILIC, ERDEM
AYHAN, S
OZARAS, N
Karatoprak, CUMALİ
YILDIZ, KEMALETTİN
YILDIZ, RS
ZORLU, MEHMET
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Abstract
Background: Endocan is a recently introduced marker of endothelial dysfunction. The objective
of this study was to compare serum endocan levels in patients with restless legs syndrome
(RLS) and control subjects in order to elucidate whether RLS is associated with endothelial
dysfunction.
Methods: A total of 31 drug naïve female patients with RLS and 31 age- and BMI-matched
women were included in the study. Patients with pathological or physiological conditions or
with a history of medication use that could potentially influence endothelial functions were
excluded, as well as those with alcohol or drug abuse history. The two groups were compared
with routine blood tests and serum endocan levels.
Results: Patients with RLS had lower serum endocan levels than the controls (P=0.037).
There was a negative bivariate correlation between RLS severity score and serum endocan
levels (r=-0.406, P=0.023). While white blood cell count was significantly higher in RLS
group, 25-hydroxy vitamin D3, vitamin B12, transferrin saturation rate, and HDL-cholesterol
were significantly lower. Creatininemia and diastolic blood pressure were also marginally
insignificantly lower in RLS group. Due to the presence of differences between two groups in
these variables, a linear regression analysis was performed that showed a positive association
between endocan and creatininemia (β=0.310, P=0.022), and a negative association between
endocan and RLS (β=-0.502, P,0.001).
Conclusion: The results of this study seem to suggest that patients with RLS may have better
endothelial functions when compared with the general population and that these patients may
be better protected against atherosclerosis
Description
Keywords
restless legs syndrome
Citation
CELIK K., ÇıKRıKÇıOĞLU M., HALAC G., KILIC E., AYHAN S., OZARAS N., YILDIZ K., YILDIZ R., ZORLU M., Karatoprak C., et al., -Serum endocan levels in women with restless legs syndrome.-, Neuropsychiatric disease and treatment, cilt.11, ss.2919-25, 2015