Publication:
A Study On Synthesis, Biological Activities and Molecular Modelling of Some Novel Trisubstituted 1,2,4-Triazole Derivatives

No Thumbnail Available
Date
2018-08-23
Authors
Gultekin, Ergun
KOLCUOĞLU, YAKUP
Akdemir, ATİLLA
Sirin, Yakup
Bektas, Hakan
BEKİRCAN, OLCAY
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue

Metrics

Search on Google Scholar

Abstract
In this study, 1-(4-substitued benzyl)-3,5-diphenyl-1H-1,2,4-triazoles (2 a-e) and ethyl(3,5-diphenyl-/H-1,2,4-triazole-1-yl) acetate (3) were synthesized starting from 3,5-diphenyl-/H1,2,4-triazole (1). The ethyl acetate derivative (3) was converted to 2-(3,5-diphenyl-1H-1,2,4-triazole-1-yl)acetohydrazide (4) in ethanolic medium with hydrazine hydrate. The reaction of the acetohydrazide (4) with suitable isothiocyanates generate 2-[(3, 5-diphenyl-1H-1,2,4-triazole-1-yl)acetyl]-4-methyl/phenyh-Ithiosemicarbazide (5a,b). The cyclization of the thiosemicarbazide (5a,b) in the presence of NaOH (2 M) resulted in the formation of 5-[(3,5-diphenyl-1H-1,2,4-triazole-1-yl)methyl]-4methyl/phenyl-2,4-dihidro-3H-1,2,4-triazole-3-thiol (6a,b). Finally, the synthesized 1,2,4-triazole-3-thiols (6a,b) were converted to their 5-substituebenzyl derivatives (7 a-j). All of the synthesized compounds (1-7) were also examined for antioxidant capacities, and antiurease and anti-acetylcholinesterase (anti-AChE) activities. It has been found that antioxidant capacity and anti-urease activity of the compound 7f is very good in biochemically active compounds.
Description
Keywords
Citation
Gultekin E., KOLCUOĞLU Y., Akdemir A., Sirin Y., Bektas H., BEKİRCAN O., -A Study On Synthesis, Biological Activities and Molecular Modelling of Some Novel Trisubstituted 1,2,4-Triazole Derivatives-, CHEMISTRYSELECT, cilt.3, ss.8813-8818, 2018
Page Views

1

File Downloads

0

Sustainable Development Goals