Publication: Serum and biliary MMP-9 and TIMP-1 concentrations in the diagnosis of cholangiocarcinoma
Loading...
Date
2015-01-01
Authors
Ince, ALİ TÜZÜN
YILDIZ, Kemal
GANGARAPU, Venkatanarayana
KAYAR, Yusuf
BAYSAL, Birol
KARATEPE, Oguzhan
Kemik, Ahu Sarbay
Senturk, HAKAN
Journal Title
Journal ISSN
Volume Title
Publisher
Metrics
Abstract
Aim: Cholangiocarcinoma is generally detected late in the course of disease, and current diagnostic techniques often fail to differentiate benign from malignant disease. Ongoing biomarker studies for early diagnosis of
cholangiocarcinoma are still continues. By this study, we analyzed the roles of serum and biliary MMP-9 and TIMP-1
concentrations in the diagnosis of cholangiocarcinoma. Materials and methods: The 113 patients (55 males, 58
females) were included; 33 diagnosed with cholangiocarcinoma (malignant group) and 80 diagnosed with choledocholithiasis (benign group). MMP-9 and TIMP-1 concentrations were analyzed in serum and bile and compared in
the malignant and benign groups. Results were evaluated statistically. Results: Biliary MMP-9 concentrations were
significantly higher (576 ± 209 vs. 403 ± 140 ng/ml, p < 0.01) and biliary TIMP-1 concentrations were significantly
lower (22.4 ± 4.9 vs. 29.4 ± 6.1 ng/ml, p < 0.01) in the malignant than in the benign group. In contrast, serum
MMP-9 and TIMP-1 concentrations were similar in the two groups. Receiver operating curve analysis revealed that
the areas under the curve of bile MMP-9 and TIMP-1 were significantly higher than 0.5 (p < 0.001). The sensitivity,
specificity, positive and negative predictive values, positive and negative likelihood ratios and accuracy were 0.94,
0.32, 0.36, 0.93, 1.40, 0.19 and 0.5 for biliary MMP-9, respectively, and 0.97, 0.36, 0.39, 0.97, 1.5, 0.08 and 0.54
for biliary TIMP-1, respectively. Conclusion: Serum and biliary MMP-9 and TIMP-1 tests do not appear to be useful
in the diagnosis of cholangiocarcinoma.
Description
Keywords
Citation
Ince A. T. , YILDIZ K., GANGARAPU V., KAYAR Y., BAYSAL B., KARATEPE O., Kemik A. S. , Senturk H., -Serum and biliary MMP-9 and TIMP-1 concentrations in the diagnosis of cholangiocarcinoma-, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, cilt.8, ss.2734-2740, 2015