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Hepatosteatoz ve omentin-1 ilişkisi / Relationship between hepatosteatosis and omentin-1

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Date
2020
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Nursoy, Hatice
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Bezmialem Vakıf University
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Abstract
Background: Childhood obesity is an increasing problem in Turkey and all over the world and is associated with several comorbidities. Hepatosteatosis (NAFLD) is the most common liver disease in children and is closely associated with obesity. Omentin-1 is an adipokine which has been found to be negatively corralated with body mass index and insulin sensitizing effect. The relationship between insulin resistance and hepatosteatosis is well documented, because of that it may be assumed that the omentin-1 may have a role in the pathogenesis of hepatosteatosis. Omentin-1 levels have been studied in obese children, but there are not enough studies in the literature regarding omentin-1 levels in obese children with hepatosteatosis. In this study, we aimed to reveal the possible relationship between omentin-1 and hepatosteatosis in childhood by examining omentin-1 levels in obese children with and without hepatosteatosis and to contribute to elucidating the pathogenesis of hepatosteatosis. Material and methods: Between October 2017 and April 2018, 134 patients aged 12-18 years with puberty (puberty stage ≥ 3) and obesity (body mass index standard deviation score (BMI SDS) ≥ 95%) admitted to our pediatric endocrinology and general pediatric outpatient clinic. Anthropometric measurements and routine blood tests of the patients were performed, blood pressure values were recorded. Two mililiters blood collected into serum gel tube for human omentin-1 ELISA kit. Upper abdominal ultrasonography (USG) was performed in all patients for detection and staging of hepatosteatosis (grade 1, 2 and 3). Patients with chronic disease or syndromic obesity, patient who using antidiabetic drugs and who were unable to allocate blood for omentin-1 during blood collection were excluded from the study. Results: There was no significant difference between the groups with and without hepatosteatosis in terms of age and sex. The median omentin-1 levels were 11.02 ng/ml in patients without hepatosteatosis (n = 44) and the mean omentin-1 levels were 10.50 ng/ml in patients with hepatosteatosis (n = 38). There was no statistically significant difference between the two groups ((p=0.823). The median omentin-1 levels in patients with severe hepatosteatosis (stage 2-3) were 9.45 ng/ml, and the median omentin-1 levels in patients with mild hepatosteatosis (stage 1) were 9.75 ng/ml (p=0.953). Conclusion: In our study, no significant relationship was found between hepatosteatosis and omentin-1 levels in obese children. However, there is a need for studies with larger sample size in which patients grade 2-3 hepatosteatosis will be compared with healthy controls and obese patients without hepatosteatosis. Clarifying the role of Omentin-1 in hepatitis-forming conditions may also contribute to understanding its role in the pathogenesis of NAFLD.
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Thesis (Medical)--Bezmialem Vakıf University, Faculty of Medicine, Department of Child Health and Diseases, Istanbul, 2020
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Çocuk Sağlığı ve Hastalıkları = Child Health and Diseases
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