Publication: Comparison of ketamine-propofol and ketamine-dexmedetomidine combinations in children for sedation during tooth extraction
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Date
2017-05-01
Authors
Authors
Canpolat, Dilek Gunay
Yildirim, Mustafa Denizhan
Kutuk, Nukhet
DOĞRUEL, FATMA
Ocak, Hakan
AKSU, RECEP
Alkan, ALPER
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Abstract
Objective: To evaluate the efficiency of ketamine-propofol and ketamine-dexmedetomidine drugs in children for
sedation during tooth extraction.
Methods: The randomised, prospective study was conducted at the Department of Oral and Maxillofacial Surgery,
Faculty of Dentistry, Erciyes University, Kayseri, Turkey, from September to November 2013, and comprised children
who were due to undergo tooth extraction. Non-invasive blood pressures (systolic and diastolic), peripheral oxygen
saturation, heart and respiratory rates and Ramsay Sedation Scores were assessed at baseline, after applying the
drugs and then every 5 minutes thereafter. Further, the ketamine-propofol group received 1mg kg-1 of ketamine
and propofol, and the ketamine-dexmedetomidine group received 1mg kg-1 of ketamine + 0.5 µg kg1 of
dexmedetomidine.
Results: Of the 60 participants, there were 30 (50%) in each group. No statistically significant differences were found
in terms of heart rate, non-invasive blood pressures at any time and the number of drug repetitions (p>0.05).
Nausea-vomiting was statistically higher in the ketamine-dexmedetomidine group (p<0.05).
Conclusion: Ketamine-propofol might be a better option due to lower vomiting and nausea episodes and higher
surgeon satisfaction levels.
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Keywords
Dexmedetomidine, Ketamine, Propofol, Tooth extraction
Citation
Canpolat D. G. , Yildirim M. D. , Kutuk N., DOĞRUEL F., Ocak H., AKSU R., Alkan A., -Comparison of ketamine-propofol and ketamine-dexmedetomidine combinations in children for sedation during tooth extraction-, JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION, cilt.67, ss.693-697, 2017