Publication:
New Fetal Dose Estimates from F-18-FDG Administered During Pregnancy: Standardization of Dose Calculations and Estimations with Voxel-Based Anthropomorphic Phantoms

Loading...
Thumbnail Image
Date
2016-11-01
Authors
Zanotti-Fregonara, Paolo
Chastan, Mathieu
Edet-Sanson, Agathe
Ekmekcioglu, Ozgul
Erdogan, EZGİ BAŞAK
Hapdey, Sebastien
Hindie, Elif
Stabin, Michael G.
Journal Title
Journal ISSN
Volume Title
Publisher
Research Projects
Organizational Units
Journal Issue

Metrics

Search on Google Scholar

Abstract
Data from the literature show that the fetal absorbed dose from 18F-FDG administration to the pregnant mother ranges from 0.5E-2 to 4E-2 mGy/MBq. These figures were, however, obtained using different quantification techniques and with basic geometric anthropomorphic phantoms. The aim of this study was to refine the fetal dose estimates of published as well as new cases using realistic voxel-based phantoms. Methods: The 18F-FDG doses to the fetus (n = 19; 5-34 wk of pregnancy) were calculated with new voxel-based anthropomorphic phantoms of the pregnant woman. The image-derived fetal time-integrated activity values were combined with those of the mothers' organs from the International Commission on Radiological Protection publication 106 and the dynamic bladder model with a 1-h bladder-voiding interval. The dose to the uterus was used as a proxy for early pregnancy (up to 10 wk). The time-integrated activities were entered into OLINDA/EXM 1.1 to derive the dose with the classic anthropomorphic phantoms of pregnant women, then into OLINDA/EXM 2.0 to assess the dose using new voxel-based phantoms. Results: The average fetal doses (mGy/MBq) with OLINDA/EXM 2.0 were 2.5E-02 in early pregnancy, 1.3E-02 in the late part of the first trimester, 8.5E-03 in the second trimester, and 5.1E-03 in the third trimester. The differences compared with the doses calculated with OLINDA/EXM 1.1 were +7%, +70%, +35%, and -8%, respectively. Conclusion: Except in late pregnancy, the doses estimated with realistic voxelwise anthropomorphic phantoms are higher than the doses derived from old geometric phantoms. The doses remain, however, well below the threshold for any deterministic effects. Thus, pregnancy is not an absolute contraindication of a clinically justified 18F-FDG PET scan.
Description
Keywords
18F-FDG, PET, Dosimetry, Pregnancy, Radiation safety, Radiobiology/dosimetry
Citation
Zanotti-Fregonara P., Chastan M., Edet-Sanson A., Ekmekcioglu O., Erdogan E. B. , Hapdey S., Hindie E., Stabin M. G. , -New Fetal Dose Estimates from F-18-FDG Administered During Pregnancy: Standardization of Dose Calculations and Estimations with Voxel-Based Anthropomorphic Phantoms-, JOURNAL OF NUCLEAR MEDICINE, cilt.57, ss.1760-1763, 2016
Collections
Page Views

0

File Downloads

9

Sustainable Development Goals