Publication: Prenatal exposure of diclofenac sodium alters the behavioral development of young Wistar rats.
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Date
2019-10-14
Authors
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Elibol, BİRSEN
Aritan, Oğur
Doğru, H
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Abstract
Diclofenac sodium (DS), a potent inhibitor of cyclooxygenase, reduces the release of arachidonic acid and formation of
prostaglandins. Being a nonsteroid drug that shows antiinflammatory action, the possible side effects of fetal DS administration gain
importance in public and medical applications. Herein, the effects of DS administration (1 mg/kg) during gestational days 5–20 were
investigated on the performance of Wistar rat pups in a variety of behavioral tasks. Four-week-old pups were subjected to sensory motor
tests, a plus maze, an open field, the Morris water maze, and a radial arm maze. Fetal DS disrupted some sensory motor performances,
such as visual placing and climbing in both females and males. In the open field, DS females had a higher level of anxiety and male DS
pups habituated to the environment slowly compared to controls. The DS pups showed slower rates of learning, whereas no substantial
between-group differences were found in the performance of spatial memory compared to both controls. Furthermore, working memory
was negatively affected by fetal DS. In conclusion, it was indicated that DS administration during pregnancy had slight behavioral
impacts with a delay in learning and a defect in the short-term memory in juvenile rats.
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Citation
Elibol B., Aritan O., Doğru H., -Prenatal exposure of diclofenac sodium alters the behavioral development of young Wistar rats.-, Turkish journal of biology = Turk biyoloji dergisi, cilt.43, ss.305-313, 2019