Tıp Fakültesi

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  • PublicationMetadata only
    International Congress On Health Law
    (2018-12-01) Dündar, Tolga Turan; DÜNDAR, TOLGA TURAN
  • PublicationMetadata only
    A COMPARATIVE STUDY OF PARATHYROID TRANSPORT SOLUTION AND UNIVERSITY OF WISCONSIN SOLUTION: EFFECT ON CALCIUM-SENSING RECEPTOR AND VITAMIN-D RECEPTOR DURING COLD ISCHEMIA IN PARATHYROID TISSUE
    (2019-10-01) Goncu, Beyza; Yucesan, Emrah; Ozdemir, Burcu; Akbaş, Fahri; Kazancıoğlu, Rümeyza; Aysan, Erhan; GÖNCÜ, BEYZA SERVET; AKBAŞ, FAHRİ; KAZANCIOĞLU, RÜMEYZA
  • PublicationOpen Access
    Psychiatric comorbidity in children with psychogenic and functional breathing disorders.
    (2019-11-11) Orengul, ABDURRAHMAN CAHİD; Ertaş, E; Ustabas, Kahraman; Yazan, H; Nursoy, MA; ÖRENGÜL, ABDURRAHMAN CAHİD; USTABAŞ KAHRAMAN, FEYZA; ÇAKIR, ERKAN; NURSOY, MUSTAFA ATİLLA
    Background: The present study aims to assess psychiatric diagnoses in children with psychogenic and functional breathing disorders (PFBD), which consist of children with psychogenic cough, throat-clearing tics, and sighing dyspnea, and compare them to a control group without any diagnosis of chronic medical problems. Methods: The participants consist of 52 children with PFBD and 42 children without any chronic medical problems. Psychiatric diagnoses were assessed via semistructured psychiatric interviews in both groups. Results: The two groups did not differ on age (PFBD group 11.25 ± 2.61, control group 11.17 ± 2.58; t = 0.14, P = .88) or sex (48.1% of the PFBD group were female, 61.9% of the control group were female; χ2 = 1.79, P = .18). 55.8% of the PFBD group and 28.6% of the control group had at least one psychiatric diagnosis according to the semistructured interviews (χ2 = 6.99, P = .008). The most common psychiatric diagnoses in the PFBD group were attention deficit hyperactivity disorder (ADHD; 17.3%), tic disorders, (15.4%), and specific phobia (15.4%). 11.5% of the cases in the PFBD group were diagnosed with somatic symptom disorder and more than half of the patients (n = 27 (51.9%)) showed clinical characteristics of tic disorders. Conclusion: Psychiatric diagnoses are common in children with PFBD, and teamwork involving child psychiatrists may be essential for the management of children with PFBD.
  • PublicationMetadata only
    Psychopathology and Associated Risk Factors Among Forcibly Displaced Syrian Children and Adolescents.
    (2018-06-01) Gormez, V; Kılıç, HN; Orengul, ABDURRAHMAN CAHİD; Demir, MN; Demirlikan, Ş; Demirbaş, S; Babacan, B; Kınık, K; Semerci, B; ÖRENGÜL, ABDURRAHMAN CAHİD
  • PublicationOpen Access
    Glomus tumor of the stomach
    (2018-03-01) YILDIZ, PELİN; GÜCİN, ZÜHAL; ARICI, DİLEK SEMA; MALYA, FATMA ÜMİT; Baysal, Birol; YILDIZ, PELİN; GÜCİN, ZÜHAL; ARICI, DILEK SEMA; MALYA, FATMA ÜMİT
    Glomus tumor is a rare benign mesenchymal neoplasm derived from the glomus body, an arteriovenous shunt mainly located in dermis and subcutis. The most common localization of this tumor is extremities, especially nailbed. Glomus tumor in the gastrointestinal system is a rare condition. Here we report a gastric glomus tumor to raise awareness of this tumor and show the difficulties in the diagnosis.
  • PublicationMetadata only
    Comparison of Different Decision Support Software Programs in Perspective of Potential Drug-Drug Interactions In Oncology Clinic
    (2019-10-23) Bektay, Muhammed Yunus; Şeker, Zehra; Eke, Hatice Kübra; Türk, Hacı Mehmet; İzzettin, Fikret Vehbi
    Background and Objective: Cancer treatment is one the most compelling situation for healthcare providers. The situation itself already complicated enough. In addition, cancer treatment requires multiple medication usage simultaneously. Drug-drug interactions (DDI) compose 20-30% of adverse effects. Drug-drug interactions are responsible 4% of mortality in oncology. Cancer patients are more prone to experience drug-drug interactions, because of taking multiple medications with anticancer agents to reduce or prevent the side effects that are caused by chemotherapeutic agents.Since the clinical pharmacists have a key role to prevent DDIs and to enhance the patients’ quality of life, a multidisciplinary approach is an important necessity in cancer care.Setting and Method: Cross-sectional observational study was conducted through interviews with 133 patients. In our study we would like to evaluate DDIs of patient who applied Oncology clinic of Bezmialem Vakif University Istanbul Turkey. This study has been approved by noninvasive Clinical Research Ethics Committee of Bezmialem Vakif University with decision number of 21/286 on 21.112017. Drug-drug interactions were evaluated using three sources: Lexicomp®, Medscape® and Micromedex®. Interaction levels have been taking into consideration were serious-use alternative and monitor closely for Medscape®, Serious-Use Alternative and Major Micromedex® and Category X and D for Lexicomp®.Main outcome measures: Evaluation of DDIs in perspective of number and comparison between different clinical decision support systems.Results: 244 different medicine prescribed 1712 times to 133 patients. According to our results number of DDIs were 265-1472 (1,99-11,07 DDI/patient) for Medscape®, 38-1006 (0,29-7,56 DDI/patient) for Micromedex and for Lexicomp® were 86-532 (1,99-4,00 DDI/patient).Conclusion: This study revealed that DDIs is common problem among oncology patients in hospital settings. When pharmacist making a decision using various software and decision support systems with different level of evidences. This study showed us that trusting one software completely could lead clinician to failure. On the other hand, patients with comorbidities, renal impairment and polypharmacy are more prone to have more DRPs.
  • PublicationOpen Access
    Longitudinal Follow-Up of Two Patients with Dysspondyloenchondromatosis due to Novel Heterozygous Mutations in COL2A1
    (2018-01-01) Gunes, Nilay; YEŞİL, GÖZDE; Beng, Kubilay; Kahraman, Sinan; Tuysuz, Beyhan; YEŞİL, GÖZDE
    Dysspondyloenchondromatosis (DSC) is a rare form of generalized enchondromatosis and characterized by short stature with unequal limb length, multiple enchondromas in metaphyseal and diaphyseal parts of the long tubular bones, and progressive kyphoscoliosis. Although the COL2A1 gene mutation was found to be responsible for DSC, a case of DSC with no pathogenic mutation in the COL2A1 gene has also been reported, suggesting that the condition is genetically heterogeneous. Here, we report 2 novel heterozygous mutations in COL2A1 in 2 patients with DSC. They had prenatal onset short stature with unequal limb length and generalized enchondroma-like lesions in metaphyseal and diaphyseal parts of the long tubular bones, and osteopenia. The first patient was diagnosed at 3 months of age and followed for 10.5 years. Severe lumbosacral scoliosis and recurrent fractures were observed. The second patient was diagnosed at the age of 4 years. Mild deterioration in scoliosis was observed during the 3-year-long follow-up period. However, skeletal radiography of both patients showed the improvement of enchondromatous lesions. In conclusion, we verified that the COL2A1 gene mutations are responsible for the DSC phenotype. We observed severe osteopenia and fractures which were not reported previously
  • PublicationMetadata only
    Recurrent Hypoglycemia in a Preschooler Girl with Overgrowth: Isolated ACTH-Deficiency with a Novel TPIT Mutation
    (2018-01-01) Abali, Zehra Yavas; YEŞİL, GÖZDE; KIRKGÖZ, TARIK; KAYGUSUZ, SARE BETÜL; Turan, Serap; BEREKET, ABDULLAH; GÜRAN, TÜLAY; YEŞİL, GÖZDE
  • PublicationMetadata only
    Serological profiles of HBV among HIV-infected patients in Istanbul, Turkey
    (2018-08-01) Kumbasar Karaosmanoğlu, Hayat; METE, BİLGÜL; Gündüz, Alper; ALTUNTAŞ AYDIN, ÖZLEM; Sargın, Fatma; YILDIZ, GÜLSEN; DURDU, BÜLENT; DÖKMETAŞ, İLYAS; TABAK, ÖMER FEHMİ; DURDU, BÜLENT
  • PublicationMetadata only
    Report of a Patient With Temple-Baraitser Syndrome
    (2014-03-01) YEŞİL, GÖZDE; Guler, Serhat; Yuksel, Adnan; ALANAY, Yasemin; YEŞİL, GÖZDE
  • PublicationMetadata only
    Hastanelerde Legionella Kontrolü
    (2018-12-16) DURDU, BÜLENT; DURDU, BÜLENT
  • PublicationOpen Access
    A case with Rubinstein-Taybi syndrome: A novel frameshift mutation in the CREBBP gene
    (2017-09-01) Eser, Metin; Ayaz, Akif; YEŞİL, GÖZDE; YEŞİL, GÖZDE
    Rubinstein-Taybi syndrome (RSTS) is a developmental disorder characterized by a wide spectrum of multiple congenital anomalies and cognitive impairment. RSTS is primarily due to mutations in CREBBP (approximately 55% of cases) or EP300 (approximately 8% of cases) genes. A 2 month-old boy had atypical facial findings such as low anterior hairline, triangular face, hirsutism on forehead, down-slanting palpebral fissures, beaked nose, broad nasal bridge, triangular mouth and pointed chin and skeletal finding including broad great thumbs and halluces, and accessory nipple. With this paper, we reported a novel frameshift mutation which is led to premature stop codon in CREBBP gene. As a result, c.2057dupC, reported in this paper enlarges the molecular spectrum of disease-causing CREBBP gene.
  • PublicationOpen Access
  • PublicationMetadata only
    Vakıf Kuran Kadınlar
    (2019-05-01) Yıldırım, Nuran; YILDIRIM, NURAN
  • PublicationMetadata only
    Rare cause of severe hypertension in an adolescent boy presenting with short stature: Questions.
    (2019-09-16) Yavas, Abali; Yesil, GÖZDE; Kirkgoz, T; Cicek, N; Alpay, H; Turan, S; Bereket, A; Guran, T; YEŞİL, GÖZDE
  • PublicationMetadata only
    The seroprevalence of toxoplasma in healthy pregnants and evaluation of IgG aviditiy values
    (2017-01-01) DURDU, BÜLENT; Mutlu, Meral; DURDU, BÜLENT
    Objective: Toxoplasmosis involving all organs is a protozoal infection caused by Toxoplasma gondii. It is usually asymptomatic. Since T. gondii is very difficult to show directly or to produce on cultural media in diagnosis serological methods are preferred. But IgM antibodies which occur in the acute phase lasts very long in serum. So this leads to wrong acute infection diagnoses. Studies conducted show us that low avidity means the infection occurred in the last 3-4 months, high avidity means the infection occurred at least 6 months before. Due to this, avidity tests are used often in differentiation between acute and chronic disease. In our study we aimed to determine Toxoplasma seroprevalence and avidity values in pregnants.
  • PublicationMetadata only
    Rare cause of severe hypertension in an adolescent boy presenting with short stature: Answers.
    (2019-09-16) Yavas, Abali; Yesil, GÖZDE; Kirkgoz, T; Cicek, N; Alpay, H; Turan, S; Bereket, A; Guran, T; YEŞİL, GÖZDE
  • PublicationOpen Access
    Assessment of the 24th Week Success of Anti-Retroviral Therapy in the Action against HIV in Istanbul Database: Results from a Region with Increasing Incidence
    (2019-05-01) Bolukçu, Sibel; METE, BİLGÜL; Gündüz, Alper; Karaosmanoglu, Hayat Kumbasar; Sargın, Fatma; DURDU, BÜLENT; Aydin, Ozlem Altuntas; Yildiz, Dilek; DÖKMETAŞ, İLYAS; Asian, Turan; TABAK, ÖMER FEHMİ; BOLUKÇU, SİBEL; DURDU, BÜLENT
    We aimed to assess the 24-week virological and immunological success of the treatment of treatment-naive and treatment-experienced patients included in the Action against HIV in Istanbul (ACTHIV-IST) database. The ACTHIV-IST database was screened retrospectively from January 2012 to January 2014. The data for these patients such as age, sex, treatment-naive or treatment-experienced status, date of diagnosis, date of commencing antiretroviral therapy, antiretroviral therapy regimen, CD4+ cell count, and viral load before and after therapy were analyzed. In the 24th week of antiretroviral therapy, there were 40 (17.9%) and 29 (14.1%) virological and immunological failures, respectively. Virological failure (VF) was associated with a baseline viral load > 100,000 copies (p = 0.004). A CD4+ cell count lower than 200 cells/µl was not found to be associated with VF (p = 0.843). Immunological failure was substantially rare in patients with a baseline CD4+ cell count > 200 cells/µl (p = 0.005). Although an HIV-RNA 侑 100,000 copies/ml was protective against VF in the 24th week, in individuals with an HIV-RNA > 100,000 copies/ml, VF was 3.2 times more likely to occur. Baseline VF was the most predictive parameter to estimate 24th week virological success and VF. VF is an important prognostic parameter resulting in CD4+ cell depletion, AIDS-related events, and increased mortality.
  • PublicationMetadata only
    Early diagnosed cerebrotendinous xanthomatosis patients: clinical, neuroradiological characteristics and therapy results of a single center from Turkey
    (2019-09-01) Zubarioglu, Tanyel; Kiykim, Ertugrul; YEŞİL, GÖZDE; Demircioglu, Duhan; Cansever, Mehmet Serif; Yalcinkaya, Cengiz; Aktuglu-Zeybek, Cigdem; YEŞİL, GÖZDE
    Cerebrotendinous xanthomatosis (CTX) is a lipid storage disorder caused by defective sterol 27-hydroxylase activity. In spite of subtle clinical signs beginning from childhood, CTX is generally diagnosed lately. The aim of this study is to evaluate clinical, neuroradiological findings and therapy responses of pediatric CTX patients and raise awareness to early features of disease. Patients who were molecularly diagnosed as CTX before 18 years of age were included in study. Clinical, epidemiological, radiological and genotypic features of patients and chenodeoxycholic acid (CDCA) therapy responses were reviewed retrospectively. Six patients were enrolled in the study. The mean age of diagnosis was 11.1 +/- 4.5 years. Apart from previous studies, predominance of cerebellar signs over pyramidal signs, peripheral neuropathy with demyelinating neuropathy in majority of patients and pathological brain imaging findings despite young ages of patients were observed. Intention tremor was the consisting finding of all patients. Optic disc drusen was initially reported in one patient. Skeletal system involvement as coarse extremities, deformities and early osteoporosis was recognized in four patients. CDCA therapy improved or at least stabilized neurological functions in all patients. This study is the first CTX series from Turkey and performed among only in early diagnosed patients with a therapy follow-up contrary to limited data in the literature. We suggest that, awareness of intention tremor and ataxic gait in addition to mental retardation, peripheral neuropathy and early osteoporosis can be suspicious for CTX and lead diagnosis. Early treatment can provide stability and may also ameliorate existing neurological findings.
  • PublicationMetadata only
    ASSOCIATION BETWEEN MIGRAINE AND ALLERGIC RHINITIS IN CHILDHOOD AND ADOLESCENCE
    (2016-05-01) Guler, Serhat; Sakalli, Erdal; YEŞİL, GÖZDE; YEŞİL, GÖZDE
    Objective: Migraine and allergic rhinitis (AR) represent common childhood and adolescent conditions. The aim of this study to assess AR prevalence, treatment outcome, and clinical issues in childhood and adolescence migraine patients.