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Mucinous Pancreatic Cysts: Comparison of Cyst Size and Location in Certain Mucinous Cyst Subgroups

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dc.contributor.authorKÖKER, İBRAHİM HAKKI
dc.contributor.authorElagoz, Sahende
dc.contributor.authorGÜCİN, ZÜHAL
dc.contributor.authorMALYA, FATMA ÜMİT
dc.contributor.authorŞENTÜRK, HAKAN
dc.contributor.institutionauthorKÖKER, İBRAHİM HAKKI
dc.contributor.institutionauthorGÜCİN, ZÜHAL
dc.contributor.institutionauthorMALYA, FATMA ÜMİT
dc.contributor.institutionauthorŞENTÜRK, HAKAN
dc.date.accessioned2021-10-19T20:59:18Z
dc.date.available2021-10-19T20:59:18Z
dc.date.issued2021-09-01T00:00:00Z
dc.description.abstractBackground: There are studies reporting that the location of intraductal papillary mucinous neoplasia (IPMN) predicts malignancy. Therefore, we evaluated the cyst location’s relationship with malignancy, and the possibility of using cyst size and location to distinguish between non-main duct (non-MD)-IPMNs, mucinous cystic neoplasia (MCN), and cystic pancreatic ductal adenocarcinoma (PDAC). Methods: We performed a retrospective analysis of data from 122 patients with a definite cyto-histological diagnosis of non-MDIPMNs, LR-MCNs, and cystic PDACs via endoscopic ultrasound fine-needle aspiration between October 2011 and October 2020. We grouped the cyst locations as head, uncinate, neck (HUN), and corpus or tail (CT). On histology, low-grade dysplasia and intermediategrade dysplasia were considered low risk (LR), whereas high-grade dysplasia and invasive carcinoma were considered high risk (HR). Results: Of the 122 patients (61 (50%) women, median age 61.5 years (range 19-85), there were 34 (27.9%) LR-non-MD-IPMNs, 33 (27%) HR-non-MD-IPMNs, 19 (15.6%) LR-MCNs, and 36 (29.5%) cystic PDACs. We found no significant difference between LRand HR-non-MD-IPMN locations (P = .803). Low-risk non-MD-IPMNs were significantly smaller than HR-non-MD-IPMNs (P < .001), LR-MCNs (P = .002), and cystic PDACs (P < .001). The area under the receiver operating characteristic curve (AUROC) was 0.819 (95% CI: 0.716-0.902; P < .0001), and demonstrated a cyst size cut-off <2.2 cm to differentiate LR cysts, while cysts <1.6 cm had a negative predictive value (NPV) of 100% in non-MD-IPMNs. Conclusion: Cyst location is not predictive of malignancy in non-MD-IPMNs. Low-risk non-MD-IPMNs were smaller than HR-non-MDIPMNs, LR-MCNs, and cystic PDACs. The cyst size cut-off was 2.2 cm; however, <1.6 cm had a 100% NPV differentiating LR- from HR-non-MD-IPMNs
dc.identifier.doi10.5152/tjg.2021.21318
dc.identifier.pubmed34609302
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29579
dc.identifier.wosWOS:000703346600004
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPancreatic mucinous cysts
dc.subjectcyst size
dc.subjectcyst location
dc.subjectintraductal papillary mucinous neoplasia
dc.subjectcystic pancreatic cancer
dc.titleMucinous Pancreatic Cysts: Comparison of Cyst Size and Location in Certain Mucinous Cyst Subgroups
dc.typeArticle
dspace.entity.typePublication
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local.publication.isinternational1
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relation.isAuthorOfPublication874eeba5-cd5f-4437-9bdc-55caae8104f2
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relation.isAuthorOfPublication.latestForDiscovery874eeba5-cd5f-4437-9bdc-55caae8104f2
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