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Oxidative Stress in Children with Chronic Spontaneous Urticaria

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dc.contributor.authorDILEK, Fatih
dc.contributor.authorOzceker, Deniz
dc.contributor.authorOzkaya, EMİN
dc.contributor.authorGuler, Nermin
dc.contributor.authorTamay, Zeynep
dc.contributor.authorKESGIN, Siddika
dc.contributor.authorYazici, MEBRURE
dc.contributor.authorKocyigit, ABDÜRRAHİM
dc.contributor.institutionauthorÖZKAYA, EMİN
dc.contributor.institutionauthorYAZICI, MEBRURE
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.date.accessioned2019-10-05T14:45:21Z
dc.date.available2019-10-05T14:45:21Z
dc.date.issued2016-01-01
dc.description.abstractThe pathogenesis of chronic spontaneous urticaria (CSU) has not been fully understood; nevertheless, significant progress has been achieved in recent years. The aim of this study was to investigate the possible role of reactive oxygen species (ROS) in the pathogenesis of CSU. Sixty-two children with CSU and 41 healthy control subjects were enrolled in the study. An extensive evaluation of demographic and clinical features was done, and serum oxidative stress was evaluated by plasma total oxidant status (TOS) and total antioxidant status (TAS) measurements.The median value of plasma TOS was found to be 10.49 𝜇mol H2O2 equiv./L (interquartile range, 7.29–17.65) in CSU patients and 7.68 𝜇mol H2O2 equiv./L (5.95–10.39) in the control group. The difference between the groups was statistically significant (𝑝 = 0.003). Likewise, the median plasma TAS level in the CSU group was decreased significantly compared to that of the control group (2.64 [2.30–2.74] versus 2.76 [2.65–2.86] mmol Trolox equiv./L, resp., 𝑝 = 0,001). Our results indicated that plasma oxidative stress is increased in children with CSU when compared to healthy subjects, and plasma oxidative stress markers are positively correlated with disease activityen
dc.description.sponsorshipBezmiâlem Vakıf Üniversitesi
dc.identifier10.5799/ahinjs.01.2013.04.0327
dc.identifier.citationDILEK F., Ozceker D., Ozkaya E., Guler N., Tamay Z., KESGIN S., Yazici M., Kocyigit A., -Oxidative Stress in Children with Chronic Spontaneous Urticaria-, OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016
dc.identifier.doi10.1155/2016/3831071
dc.identifier.pubmed27127547
dc.identifier.scopus84965172935
dc.identifier.urihttps://hdl.handle.net/20.500.12645/4662
dc.identifier.wosWOS:000376309400001
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleOxidative Stress in Children with Chronic Spontaneous Urticaria
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJournal of Clinical and Experimental Investigations
local.avesis.id726e644a-e1a9-446f-a7fd-4ecfa7d5a40e
local.avesis.response4532
local.publication.isinternational1
relation.isAuthorOfPublicationd8344ed6-8a73-476e-8a60-b66f9cce6680
relation.isAuthorOfPublication1a3ffc49-d487-4940-925a-2461b52d8474
relation.isAuthorOfPublication75babbd2-f46b-4121-aa00-54d883a6f907
relation.isAuthorOfPublication.latestForDiscoveryd8344ed6-8a73-476e-8a60-b66f9cce6680
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