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The Effects of Peroxiredoxin 6 Gene rs41055489 Variation on Oxidative Stress Mechanisms in Human Model Organism

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dc.contributor.authorAtasayar Unver, Zeynep
dc.contributor.authorKoldemir Gunduz, Meliha
dc.contributor.authorKAYHAN, FİGEN ESİN
dc.contributor.authorKaymak, Gulliu
dc.contributor.authorZengin, Ulgen
dc.contributor.authorCagatay, Penbe
dc.contributor.authorSusleyici Duman, Belgin
dc.date.accessioned2020-10-29T22:24:18Z
dc.date.available2020-10-29T22:24:18Z
dc.date.issued2015-08-01T00:00:00Z
dc.description.abstractObjective: Peroxiredoxins (Prx) belong to peroxidase type enzyme group which reduce redox active cysteine residues. The aim of this study was to determine the allele frequencies of Prx 6 gene rs41055489 polymorphism in zebrafish and in which extent may improve protective measures against oxidative stress indicators. Methods: The Prx6 gene rs41055489 genotypes were determined with qPCR method in zebrafish exposed to different doses of heavy metals. Additionally, the glutathion (GSH), malondialdehide (MDA) and catalase (CAT) levels were measured. Results: The Prx6 gene rs41055489 genotype frequencies were determined respectively as 97.7% for homozygous wild type (A/A), 2.3% for heterozygous (A/C) in group. The polymorphic genotype (C/C) was not detected in our study group. Conclusion: Prx6 rs41055489 heterozygous gene polymorphism have been observed to inhibit defence mechanisms.
dc.identifier.citationAtasayar Unver Z., Koldemir Gunduz M., KAYHAN F. E. , Kaymak G., Zengin U., Cagatay P., Susleyici Duman B., -The Effects of Peroxiredoxin 6 Gene rs41055489 Variation on Oxidative Stress Mechanisms in Human Model Organism-, BEZMIALEM SCIENCE, cilt.3, ss.37-42, 2015
dc.identifier.trdizin187743
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26595
dc.identifier.wosWOS:000370840500005
dc.subjectZebra fish
dc.subjectperoxiredoxins 6 gene
dc.subjectrs41055489 polymorphism
dc.subjectheavy metal
dc.subjectoxidative stress
dc.titleThe Effects of Peroxiredoxin 6 Gene rs41055489 Variation on Oxidative Stress Mechanisms in Human Model Organism
dc.typeArticle
dspace.entity.typePublication
local.avesis.idb0bed8b2-7782-4cb9-8e41-89107be59266
local.publication.isinternational1
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