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Effects of ischemic preconditioning and iloprost on myocardial ischemia-reperfusion damage in rats

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dc.contributor.authorAy, YASİN
dc.contributor.authorKara, Ibrahim
dc.contributor.authorAydin, CEMALETTİN
dc.contributor.authorTEKER, Melike Elif
dc.contributor.authorSenol, Serkan
dc.contributor.authorInan, BEKİR
dc.contributor.authorBASEL, Halil
dc.contributor.authorUysal, Omer
dc.contributor.authorZeybek, RAHMİ
dc.contributor.institutionauthorAY, YASİN
dc.contributor.institutionauthorAYDIN, CEMALETTİN
dc.contributor.institutionauthorKAHRAMAN AY, NURAY
dc.contributor.institutionauthorİNAN, BEKİR
dc.contributor.institutionauthorUYSAL, ÖMER
dc.contributor.institutionauthorZEYBEK, RAHMİ
dc.date.accessioned2019-10-05T22:17:59Z
dc.date.available2019-10-05T22:17:59Z
dc.date.issued2013-01-01
dc.description.abstractThis study investigates the effects of cardiac ischemic preconditioning and iloprost on reperfusion damage in rats with myocardial ischemia/reperfusion. 38 male Wistar Albino rats used in this study were divided into 5 groups. The control group (Group 1) (n=6), ischemia/reperfusion (IR) group (Group 2) (n=8), cardiac ischemic preconditioning (CIP) group (Group 3) (n=8), iloprost (ILO) group (Group 4) (n=8), and cardiac ischemic preconditioning + iloprost (CIP+ILO) group (Group 5) (n=8). Pre-ischemia, 15 minutes post-ischemia, 45 minutes post-reperfusion, mean blood pressure (MBP), and heart rates (HR) were recorded. The rate-pressure product (RPP) was calculated. Post-reperfusion plasma creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), troponin (cTn) vlaues, and infarct size/area at risk (IS/AAR) were calculated from myocardial tissue samples. Arrhythmia and ST segment elevations were evaluated during the ischemia and reperfusion stages. Although the MBP, HR, RPP values, biochemical parameters of CK-MB and LDH levels, IS/AAR rates, ST segment elevation values were found to be similar in CIP and CIP+ILO groups and the IR and ILO groups (p>0.05), CIP-containing group values had a positively meaningful difference (p<0.05) compared with the IR and ILO group. While mild-moderate findings of damage were observed in Group 3 and Group 5, severely findings of damage were releaved in Group 2 and Group 4. The arrhythmia score of the ILO group was meaningfully lower (F: 41.4, p<0.001) than the IR group. We can conclude that the effects of myocardial reperfusion damage can be reduced by cardiac ischemic preconditioning, intravenous iloprost reduced the incidence of ventricular arrhythmia associated with reperfusion, and its use with CIP caused no additional changes.en
dc.identifier10.1016/j.materresbull.2012.11.032
dc.identifier.citationAy Y., Kara I., Aydin C., AY N. K. , TEKER M. E. , Senol S., Inan B., BASEL H., Uysal O., Zeybek R., -Effects of ischemic preconditioning and iloprost on myocardial ischemia-reperfusion damage in rats-, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, cilt.6, ss.516-523, 2013
dc.identifier.pubmed23936589
dc.identifier.scopus84881078326
dc.identifier.urihttps://hdl.handle.net/20.500.12645/9338
dc.identifier.wosWOS:000323568000005
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleEffects of ischemic preconditioning and iloprost on myocardial ischemia-reperfusion damage in rats
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameMATERIALS RESEARCH BULLETIN
local.avesis.ide83a01d2-2c5b-4d84-9f04-1e3968fa3a4c
local.avesis.response9214
local.publication.isinternational1
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