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Protective Effect of Curcumin on Cadmium-Induced Liver Apoptosis in Rats

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dc.contributor.authorBayindir, Nihan
dc.contributor.authorEŞREFOĞLU, MUKADDES
dc.contributor.authorKumas, Meltem
dc.contributor.authorIraz, Meryem
dc.contributor.authorKesgin, Siddika
dc.contributor.authorKilic, Elif
dc.contributor.institutionauthorBAYINDIR, NİHAN
dc.contributor.institutionauthorEŞREFOĞLU, MUKADDES
dc.contributor.institutionauthorKUMAŞ, MELTEM
dc.date.accessioned2020-01-23T20:59:22Z
dc.date.available2020-01-23T20:59:22Z
dc.date.issued2016-12-01T00:00:00Z
dc.description.abstractObjective: Cadmium (CD), which is used for many industrial purposes, is a toxic agent. CD accumulates in the liver; therefore, exposure to toxic doses of Cd results in hepatic damage. Studies in rats have shown that CD induces apoptosis in hepatocytes. Curcumin is a natural compound isolated from Curcuma longa. It has a powerful anti-inflammatory affect and scavenges reactive oxygen radicals. Additionally, it has been shown to have an anti-apoptotic effect in a dose-dependent manner. The aim of the present study was to evaluate the effects of therapeutic doses of curcumin on Cd-induced hepatic apoptosis as well as hepatic biochemical and inflammatory changes in Sprague-Dawley rats. Methods: In this study, 24 female Sprague-Dawley rats (6 months old) were randomly assigned to four main groups (n=6): control, CD, CD+curcumin, and curcumin. At the end of the experiment, after collecting blood samples from the heart, the rats were sacrificed and their livers were removed for histopathological and biochemical examinations. The number of apoptotic cells, total anti-oxidant status, total oxidant status, and thiol and MPO levels were measured in liver tissue; interleukin-6 and procalcitonin levels were measured in sera. Results: Chronic CD administration induced apoptosis. The number of apoptotic cells was significantly increased in the Cd group (almost 2 fold) compared to that in the control group. However, in the CD+curcumin group, the number of apoptotic cells was significantly decreased (almost 2 fold) compared to that in the Cd group. However, there were no statistically significant differences. Conclusion: We suggest that curcumin protects the liver against toxin-induced apoptosis.
dc.identifier.citationBayindir N., EŞREFOĞLU M., Kumas M., Iraz M., Kesgin S., Kilic E., -Protective Effect of Curcumin on Cadmium-Induced Liver Apoptosis in Rats-, BEZMIALEM SCIENCE, cilt.4, ss.99-105, 2016
dc.identifier.doi10.14235/bs.2016.714
dc.identifier.trdizin237224
dc.identifier.urihttps://openaccess.bezmialem.edu.tr/handle/20.500.12645/13487
dc.identifier.wosWOS:000390866000004
dc.subjectLiver
dc.subjectApoptosis
dc.subjectcadmium
dc.subjectcurcumin
dc.titleProtective Effect of Curcumin on Cadmium-Induced Liver Apoptosis in Rats
dc.typeArticle
dspace.entity.typePublication
local.avesis.id1e8c4392-8a0c-4d4f-a61d-39a8f27363fc
local.publication.isinternational1
relation.isAuthorOfPublication3c2743d0-b951-4eb5-bdd8-1c932e717700
relation.isAuthorOfPublicationd0c7c343-3b7d-47ef-a2a7-5169234110eb
relation.isAuthorOfPublication566662cf-8bbb-4744-bfd8-867d0784f978
relation.isAuthorOfPublication.latestForDiscovery3c2743d0-b951-4eb5-bdd8-1c932e717700
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