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Optimization of ultrasound-assisted extraction of total phenolic contents and antioxidant activity using response surface methodology from jujube leaves (Ziziphus jujuba) and evaluation of anticholinesterase inhibitory activity

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dc.contributor.authorZemouri-Alioui, Salima
dc.contributor.authorBey, Mostapha Bachir
dc.contributor.authorKurt, BELMA
dc.contributor.authorSonmez, Fatih
dc.contributor.institutionauthorZENGİN KURT, BELMA
dc.date.accessioned2019-10-05T13:20:55Z
dc.date.available2019-10-05T13:20:55Z
dc.date.issued2019-03-01
dc.description.abstractAn ultrasound-assisted procedure for the extraction of phenolics (TPC) and antioxidant activity (AA) from jujube leaves have been investigated using response surface methodology (RSM). The Box-Behnken design was used to investigate the effects of three independent variables, solvent concentration (methanol/water; 40-100%), ultrasound-intensity (20-100%), and extraction time (3-15min) on the responses. The optimal extraction conditions were 64.20% methanol, 73.60% ultrasound intensity, and 13.27min. Under optimal conditions, the corresponding experimental values for TPC and AA were 6098.14mg GAE/100g DMand 4010.63mg AAE/100g DM. The experimental values were in close agreement with those predicted values within a 99% confidence level, thus indicating the suitability of the model and the success of RSM in optimizing the ultrasound assisted extraction of TPC and AA of jujube leaves. The results showed that optimized jujube leaves extract exhibited inhibitory effects on both acetylcholinesterase and butyrylcholinesterase with IC50 of 62.30 +/- 2.54 and 147.00 +/- 2.31 mu g/mL, respectively.
dc.identifier10.1213/ane.0b013e318163fbfe
dc.identifier.citationZemouri-Alioui S., Bey M. B. , Kurt B., Sonmez F., Louaileche H., -Optimization of ultrasound-assisted extraction of total phenolic contents and antioxidant activity using response surface methodology from jujube leaves (Ziziphus jujuba) and evaluation of anticholinesterase inhibitory activity-, JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION, cilt.13, ss.321-329, 2019
dc.identifier.doi10.1007/s11694-018-9947-5
dc.identifier.scopus85055096944
dc.identifier.urihttps://hdl.handle.net/20.500.12645/1985
dc.identifier.wosWOS:000459070100033
dc.language.isoen
dc.titleOptimization of ultrasound-assisted extraction of total phenolic contents and antioxidant activity using response surface methodology from jujube leaves (Ziziphus jujuba) and evaluation of anticholinesterase inhibitory activity
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameAnesthesia and analgesia
local.avesis.id2ff1eee1-fdb6-45c2-a0ba-6e15fff556c6
local.avesis.response1855
local.publication.isinternational1
relation.isAuthorOfPublication3fd265b5-fdd8-4c56-949b-deb0303c3db7
relation.isAuthorOfPublication.latestForDiscovery3fd265b5-fdd8-4c56-949b-deb0303c3db7
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