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Early Suspicion of Heparin-Induced Thrombocytopenia for Successful Free Flap Salvage: Reports of Two Cases

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dc.contributor.authorMehdizade, Turan
dc.contributor.authorKelahmetoğlu, Osman
dc.contributor.authorGürkan, Volkan
dc.contributor.authorÇetin, Güven
dc.contributor.authorGüneren, Ethem
dc.contributor.institutionauthorKELAHMETOĞLU, OSMAN
dc.contributor.institutionauthorGÜRKAN, VOLKAN
dc.contributor.institutionauthorÇETİN, GÜVEN
dc.contributor.institutionauthorGÜNEREN, ETHEM
dc.date.accessioned2020-07-12T20:59:07Z
dc.date.available2020-07-12T20:59:07Z
dc.date.issued2020-06-01T00:00:00Z
dc.description.abstractHeparin-induced thrombocytopenia (HIT) is an underestimated complication of heparin treatment. Flap loss and related morbidity (even mortality) are caused by occlusion of the capillary vessels by a highly immunogenic complex formed by adherence of antiheparin antibodies to platelet factor 4. Early suspicion and effective treatment of HIT developing in two free flaps are described. We report on the management of two patients with HIT. Both patients were treated successfully by early suspicion and hematology consultation. Heparin products were discontinued; the patients were switched to a nonheparin anticoagulant. We emphasize the importance of early diagnosis, hematologist assessment, and a change to a nonheparin anticoagulant to prevent flap failure and possibly the catastrophic consequences of such failure.
dc.identifier.doi10.1055/s-0040-1713692
dc.identifier.pubmed34511835
dc.identifier.urihttps://hdl.handle.net/20.500.12645/18191
dc.language.isoen
dc.subjectflap
dc.subjectfondaparinux
dc.subjectheparin-induced thrombocytopenia
dc.subjectsurgery
dc.titleEarly Suspicion of Heparin-Induced Thrombocytopenia for Successful Free Flap Salvage: Reports of Two Cases
dc.typeArticle
dspace.entity.typePublication
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local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscovery3d00c2ca-d62a-43c1-8d54-74e3de96227b
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