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Targeted Nanomedicines for Cancer Therapy, From Basics to Clinical Trials

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dc.contributor.authorEskandari, Zahra
dc.contributor.authorBAHADORİ, FATEMEH
dc.contributor.authorÇELİK, BURAK
dc.contributor.authorOnyuksel, Hayat
dc.contributor.institutionauthorBAHADORİ, FATEMEH
dc.contributor.institutionauthorÇELİK, BURAK
dc.date.accessioned2020-06-05T20:59:54Z
dc.date.available2020-06-05T20:59:54Z
dc.date.issued2020-04-30T00:00:00Z
dc.description.abstractTraditional systemic chemotherapy involves the wide distribution of drug molecules in the body, causing toxic side effects in the healthy tissues and limiting the therapeutic dose required at the site of drug action. In order to decrease side effects and increase the drug efficacy, recent research on chemotherapy focuses on drug targeting. Targeted therapy can be achieved by several mechanisms including; 1) using an antibody as a drug that is specific to a disease biomarker, 2) using an antibody (or peptide) as a targeting agent conjugated to the drug molecule, 3) delivering the drug molecules to the target tissue in a nano-carrier with or without the targeting agent attached on its surface. The third approach involves the nanomedicines that can be targeted to diseased tissues by both passive (extravasating at diseased sites due to leaky vasculature) and active (specific interaction of the targeting agent with disease biomarker) targeting mechanisms. In this review we will cover the passively targeted nanomedicines prepared using nano drug carriers. Ideally the carrier particle should be in the right size (1-100nm), stable enough to prevent drug leakage during circulation, and safe not to cause any damage to healthy tissues. Competition for all these properties generated many different types of materials to be used as nanodrug delivery systems. After a brief review of most commonly used drug carriers, we discuss the clinical use of the targeted nanomedicines with regard to their pharmacokinetic and pharmacodynamics properties, and how these properties vary from conventional formulations providing free drugs in the circulation after administration.
dc.identifier.citationEskandari Z., BAHADORİ F., ÇELİK B., Onyuksel H., -Targeted Nanomedicines for Cancer Therapy, From Basics to Clinical Trials-, JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, cilt.23, ss.132-157, 2020
dc.identifier.doi10.18433/jpps30583
dc.identifier.pubmed32369437
dc.identifier.scopus85084276600
dc.identifier.urihttps://hdl.handle.net/20.500.12645/18075
dc.identifier.wosWOS:000530818000001
dc.titleTargeted Nanomedicines for Cancer Therapy, From Basics to Clinical Trials
dc.typeArticle
dspace.entity.typePublication
local.avesis.id76c0362d-f120-4608-9235-a6d68def8c56
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication14c64c63-5d3c-42d0-9f93-cf4b7af6da81
relation.isAuthorOfPublicationfb8ce36b-f920-4f90-a8b5-ea24535e608d
relation.isAuthorOfPublication.latestForDiscovery14c64c63-5d3c-42d0-9f93-cf4b7af6da81
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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