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MRS features during encephalopathic crisis period in 11 years old case with GA-1

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dc.contributor.authorKurtcan, SERPİL
dc.contributor.authorAKSU, Banu
dc.contributor.authorAlkan, ALPAY
dc.contributor.authorGULER, Serhat
dc.contributor.authorIscan, AKIN
dc.contributor.institutionauthorKURTCAN, SERPİL
dc.contributor.institutionauthorALKAN, ALPAY
dc.contributor.institutionauthorİŞCAN, AKIN
dc.date.accessioned2019-10-05T22:07:43Z
dc.date.available2019-10-05T22:07:43Z
dc.date.issued2015-05-01
dc.description.abstractGlutaric aciduria type-1 (GA-1) is a disorder of amino acid metabolism. The usual clinical-onset is an acute encephalopathic crisis in early childhood. There are only a few cases diagnosed in older age groups. MRI features of the disease are well defined. However, there are limited number of studies concerning advanced neuroimaging findings. We present DWI and MRS findings of an 11 year-old GA-1 patient admitted with an encephalopathic crisis. Diffusion restrictions in bilateral basal ganglia, corpus callosum and periventricular deep white matter were observed. In left occipital periventricular white matter and left basal ganglia, mild increased Cho/Cr and MI/Cr ratios and decreased NAA/Cr ratio were detected. Also inverted double lactate peak (TB: 135 ms) was present at 1.33 ppm in the left basal ganglia. In addition to these findings, a peak at 1.56 ppm above the baseline was seen on both short and long echo-time MRS in left occipital lobe deep white matter which may show accumulation of degradation products of amino acids in the GCDH enzyme deficiency. (Cd) 2014 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
dc.identifier10.1097/iae.0b013e3182733b97
dc.identifier.citationKurtcan S., AKSU B., Alkan A., GULER S., Iscan A., -MRS features during encephalopathic crisis period in 11 years old case with GA-1-, BRAIN & DEVELOPMENT, cilt.37, ss.546-551, 2015
dc.identifier.pubmed25277297
dc.identifier.urihttps://hdl.handle.net/20.500.12645/8976
dc.language.isoen
dc.titleMRS features during encephalopathic crisis period in 11 years old case with GA-1
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameRetina (Philadelphia, Pa.)
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local.avesis.response8852
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relation.isAuthorOfPublication12538a20-d5a6-4246-ab37-58afe7bbae72
relation.isAuthorOfPublication.latestForDiscovery12538a20-d5a6-4246-ab37-58afe7bbae72
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