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Renal tubular function and urinary N-acetyl-beta-d-glucosaminidase and kidney injury molecule-1 levels in asthmatic children

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dc.contributor.authorDEMIR, Aysegul Dogan
dc.contributor.authorGOKNAR, Nilufer
dc.contributor.authorOKTEM, Faruk
dc.contributor.authorOzkaya, EMİN
dc.contributor.authorYazici, MEBRURE
dc.contributor.authorTorun, EMEL
dc.contributor.authorVehapoglu, Aysel
dc.contributor.authorKUCUKKOC, Mehmet
dc.contributor.institutionauthorÖZKAYA, EMİN
dc.contributor.institutionauthorYAZICI, MEBRURE
dc.contributor.institutionauthorTORUN, EMEL
dc.contributor.institutionauthorVEHAPOĞLU TÜRKMEN, AYSEL
dc.date.accessioned2019-10-05T13:45:04Z
dc.date.available2019-10-05T13:45:04Z
dc.date.issued2016-12-01
dc.description.abstractBackground: Asthma is a chronic inflammatory disorder of the airways which results in chronic hypoxia. Chronic hypoxia and inflammation can affect renal tubular function. Objectives: The aim of this study was to investigate renal tubular function and early kidney injury molecules such as urinary N-acetyl-betaglucosaminidase (NAG) and kidney injury molecule-1 (KIM-1) excretion in children with asthma. Methods: Enrolled in the study were 73 children diagnosed with asthma and 65 healthy age- and gender-matched control subjects. Urine pH, sodium, phosphorus, potassium, microalbumin, creatinine, NAG, KIM-1, and serum creatinine, sodium, phosphorus were evaluated. The diagnosis of asthma and classification of mild or moderate were done according to the Global Initiative for Asthma guidelines. Results: Serum sodium, phosphorus, creatinine, and urinary microalbumin were within normal levels in the both groups. Urinary pH, sodium, potassium, phosphorus, microalbumin, and KIM-1 excretions were similar between the control and study groups. Tubular phosphorus reabsorption was within normal limits in two groups. Urine NAG was elevated in the study group (P = 0.001). Urinary KIM-1 and NAG levels were positively correlated (r = 0.837; P = 0.001). When children with mild and moderate asthma were compared, all of the parameters were similar (P >0.05). Conclusions: This study showed that chronic asthma can lead to subtle renal impacts. We suggest that in children with asthma, urinary NAG level is a more valuable parameter to show degree of renal tubular injury than markers such as microalbumin and KIM-1. Chronic hypoxy and inflammation probably contributes to these subclinical renal effects.en
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dc.identifier.citationDEMIR A. D. , GOKNAR N., OKTEM F., Ozkaya E., Yazici M., Torun E., Vehapoglu A., KUCUKKOC M., -Renal tubular function and urinary N-acetyl-beta-d-glucosaminidase and kidney injury molecule-1 levels in asthmatic children-, INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, cilt.29, ss.626-631, 2016
dc.identifier.doi10.1177/0394632016651448
dc.identifier.pubmed27272162
dc.identifier.scopus85016924191
dc.identifier.urihttps://hdl.handle.net/20.500.12645/2897
dc.identifier.wosWOS:000391564600008
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleRenal tubular function and urinary N-acetyl-beta-d-glucosaminidase and kidney injury molecule-1 levels in asthmatic children
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameCLINICAL CHEMISTRY
local.avesis.id465e0ba6-3bdc-48a5-8213-516331e5352c
local.avesis.response2767
local.publication.isinternational1
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relation.isAuthorOfPublication12c436eb-39a7-43ce-b99f-c585a4499848
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relation.isAuthorOfPublication.latestForDiscoveryd8344ed6-8a73-476e-8a60-b66f9cce6680
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