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Hematological indices for differential diagnosis of Beta thalassemia trait and iron deficiency anemia.

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dc.contributor.authorOZGURHAN, G
dc.contributor.authorDEMIR, AD
dc.contributor.authorUzuner, SELÇUK
dc.contributor.authorNURSOY, MUSTAFA ATİLLA
dc.contributor.authorTURKMEN, S
dc.contributor.authorKACAN, A
dc.contributor.institutionauthorVEHAPOĞLU TÜRKMEN, AYSEL
dc.contributor.institutionauthorUZUNER, SELÇUK
dc.contributor.institutionauthorNURSOY, MUSTAFA ATİLLA
dc.date.accessioned2019-10-05T22:07:15Z
dc.date.available2019-10-05T22:07:15Z
dc.date.issued2014-01-01
dc.description.abstractBackground. The two most frequent types of microcytic anemia are beta thalassemia trait (𝛽-TT) and iron deficiency anemia (IDA). We retrospectively evaluated the reliability of various indices for differential diagnosis of microcytosis and 𝛽-TT in the same patient groups. Methods. A total of 290 carefully selected children aged 1.1–16 years were evaluated. We calculated 12 discrimination indices in all patients with hemoglobin (Hb) values of 8.7–11.4 g/dL. None of the subjects had a combined case of IDA and 𝛽-TT. All children with IDA received oral iron for 16 weeks, and HbA2 screening was performed after iron therapy. The patient groups were evaluated according to red blood cell (RBC) count; red blood distribution width index; the Mentzer, Shine and Lal, England and Fraser, Srivastava and Bevington, Green and King, Ricerca, Sirdah, and Ehsani indices; mean density of hemoglobin/liter of blood; and mean cell density of hemoglobin. Results. The Mentzer index was the most reliable index, as it had the highest sensitivity (98.7%), specificity (82.3%), and Youden’s index (81%) for detecting 𝛽-TT; this was followed by the Ehsani index (94.8%, 73.5%, and 68.3%, resp.) and RBC count (94.8%, 70.5%, and 65.3%). Conclusion.The Mentzer index provided the highest reliabilities for differentiating 𝛽-TT from IDA.en
dc.identifier10.1016/j.comppsych.2008.09.007
dc.identifier.citationVEHAPOGLU A., OZGURHAN G., DEMIR A., Uzuner S., NURSOY M. A. , TURKMEN S., KACAN A., -Hematological indices for differential diagnosis of Beta thalassemia trait and iron deficiency anemia.-, Anemia, cilt.2014, ss.576738, 2014
dc.identifier.pubmed24818016
dc.identifier.urihttps://hdl.handle.net/20.500.12645/8954
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleHematological indices for differential diagnosis of Beta thalassemia trait and iron deficiency anemia.
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameComprehensive psychiatry
local.avesis.iddea4bb83-ed5d-4dc6-87ae-bf81af68b12a
local.avesis.response8830
relation.isAuthorOfPublicationb68333b8-8b35-4545-989f-bf6e27e7a81b
relation.isAuthorOfPublication5a52edc0-0365-409d-88ce-c6afe0470201
relation.isAuthorOfPublicatione78a6738-63a5-4f48-aac4-24de67b736cf
relation.isAuthorOfPublication.latestForDiscoverye78a6738-63a5-4f48-aac4-24de67b736cf
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