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Helicobacter Pylory infection in patients with esophageal squamous cell carcinoma

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dc.contributor.authorPOYRAZOGLU, Omer Bilgehan
dc.contributor.authorDulger, Ahmet Cumhur
dc.contributor.authorGultepe, BİLGE
dc.contributor.institutionauthorSÜMBÜL, BİLGE
dc.date.accessioned2019-10-05T21:19:36Z
dc.date.available2019-10-05T21:19:36Z
dc.date.issued2017-03-01
dc.description.abstractObjective:: Esophageal squamous cell carcinoma is one of the most common esophageal diseases in the developing world, but the relationship between esophageal squamous cell carcinoma and Helicobacter pylori infection remains a neglected topic. The primary objective of this study was to determine the association between Helicobacter pylori infection and esophageal squamous cell carcinoma. A second purpose was to determine the incidence and factors associated with Helicobacter pylori infection following esophagectomy. Method:: The microorganism was identified by testing the gastric biopsy materials from 95 esophageal squamous cell carcinoma patients (66 females; 39 were esophagectomized) for urease activity in a medium containing urea and a power of hydrogen detection reagent and comparing the results with those from a healthy population. Differences in patient characteristics were assessed with chi-square tests and t-tests for categorical and continuous factors, respectively. Results:: The patients with esophageal squamous cell carcinoma had a significantly lower prevalence of Helicobacter pylori compared with the healthy population (p<0.001). The naive and esophagectomized patients, in contrast, showed no significant differences in Helicobacter pylori infection (p>0.005). Patients with esophageal squamous cell carcinoma showed a significant association between leukocytosis and hypoglobulinemia and the presence of Helicobacter pylori infection (p=0.023 and p=0.045, respectively). Conclusion:: These results suggest that Helicobacter pylori is not an etiological factor in patients with esophageal squamous cell carcinoma. We found a statistically significant negative correlation between esophageal squamous cell cancer and Helicobacter pylori infection. These findings may guide new strategies for esophageal squamous cell carcinoma therapy.en
dc.identifier
dc.identifier.citationPOYRAZOGLU O. B. , Dulger A. C. , Gultepe B., -Helicobacter Pylory infection in patients with esophageal squamous cell carcinoma-, CLINICS, cilt.72, ss.150-153, 2017
dc.identifier.doi10.6061/clinics/2017(03)04
dc.identifier.pubmed28355360
dc.identifier.scopus85016092681
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7080
dc.identifier.wosWOS:000397874900004
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleHelicobacter Pylory infection in patients with esophageal squamous cell carcinoma
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameSBAD
local.avesis.idb0a116b3-3a21-465f-8903-a3e3364090af
local.avesis.response6956
local.publication.isinternational1
relation.isAuthorOfPublication51568f47-69f1-46a2-b201-e6d6161080a8
relation.isAuthorOfPublication.latestForDiscovery51568f47-69f1-46a2-b201-e6d6161080a8
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