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Synthesis and biological evaluation of novel coumarin-chalcone derivatives containing urea moiety as potential anticancer agents

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dc.contributor.authorKurt, BELMA
dc.contributor.authorKandas, Nur Ozten
dc.contributor.authorDAĞ, AYDAN
dc.contributor.authorSonmez, Fatih
dc.contributor.authorKucukislamoglu, Mustafa
dc.contributor.institutionauthorZENGİN KURT, BELMA
dc.contributor.institutionauthorDAĞ, AYDAN
dc.date.accessioned2020-01-16T21:00:45Z
dc.date.available2020-01-16T21:00:45Z
dc.date.issued2020-01-01T00:00:00Z
dc.description.abstractThe increasing interest on new drug discovery is constantly up to date as drugs do not increase survival adequately against increasing cancer cases worldwide. Based on the reported anticancer activity of coumarin, chalcone and urea derivatives, the present investigation dealt with the design and synthesis of coumarin derivatives bearing diversely substituted chalcone-urea moieties 5a-k. Through a structure-based molecular hybridization approach, a series of novel coumarin-chalcone derivatives containing urea moiety was synthesized and screened for their in vitro antiproliferative activities against the cancer cell lines (H4IIE and HepG2). In addition, the synthesized compounds were tested on a cell line that was not cancerous (CHO) and the damage, it could give to normal cells was determined. Among the synthesized compounds, 5k exhibited better inhibition of H4IIE compared to Sorafenib. 5j also showed better inhibition against HepG2 than Sorafenib. In particular, 5k induced H4IIE apoptosis, arrested cell cycle at the S phase. Therefore, 5k and 5j may be potent antitumor agents, representing a promising lead for further optimization. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
dc.identifier.citationKurt B., Kandas N. O. , DAĞ A., Sonmez F., Kucukislamoglu M., -Synthesis and biological evaluation of novel coumarin-chalcone derivatives containing urea moiety as potential anticancer agents-, ARABIAN JOURNAL OF CHEMISTRY, cilt.13, ss.1120-1129, 2020
dc.identifier.doi10.1016/j.arabjc.2017.10.001
dc.identifier.scopus85031745542
dc.identifier.urihttps://openaccess.bezmialem.edu.tr/handle/20.500.12645/13341
dc.identifier.wosWOS:000505076000084
dc.titleSynthesis and biological evaluation of novel coumarin-chalcone derivatives containing urea moiety as potential anticancer agents
dc.typeArticle
dspace.entity.typePublication
local.avesis.idef9506c8-3172-4d39-8ea8-c469785721ab
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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relation.isAuthorOfPublication5053fdfd-57cd-423a-9076-db4bab8cbe3d
relation.isAuthorOfPublication.latestForDiscovery3fd265b5-fdd8-4c56-949b-deb0303c3db7
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relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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