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Serum endocan levels in patients with stable COPD.

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dc.contributor.authorPihtili, AYLİN
dc.contributor.authorBINGOL, Z
dc.contributor.authorKıYAN, E
dc.contributor.institutionauthorPIHTILI, AYLIN
dc.date.accessioned2019-10-05T13:18:25Z
dc.date.available2019-10-05T13:18:25Z
dc.date.issued2018-10-15
dc.description.abstractBackground: Endothelial cell specific molecule-1, also called as endocan, is a dermatan sulfate proteoglycan, which is expressed by endothelial cells in alveolar walls of the lung and kidney. High endocan levels are found associated with endothelial dysfunction and inflammation. We hypothesize that endocan level is also high in COPD due to systemic inflammation and endothelial dysfunction. We aimed to investigate the expression of endocan in patients with stable COPD. Material and methods: The study included patients with COPD and control subjects. COPD patients were classified according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 criteria. Demographics, body mass index, smoking history, and comorbidities were recorded. Endocan levels of COPD patients and controls were compared. Results: Totally, 88 subjects (47 stable COPD patients, 41 controls) were evaluated. Endocan levels were significantly higher in COPD patients than control group (860.1±259.8 vs 647.3±316.9 pg/mL, P=0.001). There was no relationship between GOLD COPD categories and endocan levels. Also endocan levels were similar between COPD patients with or without hypoxemia. Conclusion: Serum endocan level was significantly higher in patients with stable COPD. Further studies should be performed to better understand the relationship between endocan and COPD.en
dc.identifier10.1097/scs.0000000000002027
dc.identifier.citationPihtili A., BINGOL Z., KıYAN E., -Serum endocan levels in patients with stable COPD.-, International journal of chronic obstructive pulmonary disease, cilt.13, ss.3367-3372, 2018
dc.identifier.doi10.2147/copd.s182731
dc.identifier.pubmed30410323
dc.identifier.scopus85056285285
dc.identifier.urihttps://hdl.handle.net/20.500.12645/1878
dc.identifier.wosWOS:000447524200001
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleSerum endocan levels in patients with stable COPD.
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameThe Journal of craniofacial surgery
local.avesis.id2d4581a4-7ccc-445d-ab3c-add32e2f1244
local.avesis.response1748
local.org.facultyTıp Fakültesi
local.publication.isinternational1
relation.isAuthorOfPublicationf1c1e007-88f5-4242-a4a0-60fcb5501bb9
relation.isAuthorOfPublication.latestForDiscoveryf1c1e007-88f5-4242-a4a0-60fcb5501bb9
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