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The Role of p16 and MDM2 Gene Polymorphisms in Prolactinoma: MDM2 Gene Polymorphisms May Be Associated with Tumor Shrinkage

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dc.contributor.authorTurgut, SEDA
dc.contributor.authorIlhan, Muzaffer
dc.contributor.authorTuran, Saime
dc.contributor.authorKaraman, Ozcan
dc.contributor.authorYaylim, Ilhan
dc.contributor.authorKucukhuseyin, Ozlem
dc.contributor.authorTasan, ERTUĞRUL
dc.contributor.institutionauthorTURGUT, SEDA
dc.contributor.institutionauthorİLHAN, MAHMUT MUZAFFER
dc.contributor.institutionauthorKARAMAN, ÖZCAN
dc.contributor.institutionauthorTAŞAN, ERTUĞRUL
dc.date.accessioned2019-10-05T14:55:59Z
dc.date.available2019-10-05T14:55:59Z
dc.date.issued2017-05-01
dc.description.abstractAim: Prolactinomas are thought to arise from clonal expansion of a single mutated cell which is subjected to growth stimuli of several permissive factors, although the pathogenetic mechanisms underlying tumorigenesis remain unclear. The present study aimed to investigate the role of p16 (540C→G and 580C→T) and mouse double minute 2 (MDM2) (SNP309T→G) gene polymorphisms in tumorigenesis and characteristics of prolactinoma. Patients and methods: A total of 74 patients with prolactinoma and 100 age- and gender-matched healthy individuals were enrolled in the study. Serum prolactin levels were measured by enzyme-linked immunosorbent assay (ELISA). p16 and MDM2 polymorphisms were determined by polymerase chain reaction-restriction fragment polymorphism and agarose gel electrophoresis. Results: p16 540C→G genotype distribution was found to be: CC: 66.2%, CG: 28.4%, GG: 5.4%; p16 580C→T genotype distribution was found to be: CC: 82.4%, CT: 17.6%, TT: 0% and MDM2 genotype distribution was found to be: TT: 31.1%, TG: 47.3%, GG: 21.6% in patients with prolactinoma. Tumor diameter before treatment was correlated with prolactin levels before treatment and percentage of prolactin decrease with treatment (r=0.719, p<0.001, p=0.034 r=0.256, respectively). The number of patients with tumor size decrease of more than 50% in those with homozygous genotype (TT+GG) of MDM2 SNP309T→G was significantly higher than in heterozygous genotype (TG) carriers (odds ratio(OR)=0.18, 95% confidence interval(CI)=0.06-0.58; p=0.003). Conclusion: This study showed that p16 and MDM2 polymorphisms do not play a decisive role in tumorigenesis, but some genotypes of these polymorphisms might be associated with follow-up characteristics of prolactinoma.en
dc.identifier10.1111/ijd.13101
dc.identifier.citationTurgut S., Ilhan M., Turan S., Karaman O., Yaylim I., Kucukhuseyin O., Tasan E., -The Role of p16 and MDM2 Gene Polymorphisms in Prolactinoma: MDM2 Gene Polymorphisms May Be Associated with Tumor Shrinkage-, IN VIVO, cilt.31, ss.357-363, 2017
dc.identifier.doi10.21873/invivo.11067
dc.identifier.pubmed28438863
dc.identifier.scopus85018689903
dc.identifier.urihttps://hdl.handle.net/20.500.12645/5100
dc.identifier.wosWOS:000400046000012
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleThe Role of p16 and MDM2 Gene Polymorphisms in Prolactinoma: MDM2 Gene Polymorphisms May Be Associated with Tumor Shrinkage
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameINTERNATIONAL JOURNAL OF DERMATOLOGY
local.avesis.id7dabe008-35bd-4665-8ede-7f2b1f5c2d7b
local.avesis.response4970
local.publication.isinternational1
relation.isAuthorOfPublication12091944-c47b-46a0-963a-ca315e71af7a
relation.isAuthorOfPublication03a7dcd2-c33d-41cc-96f8-cb42f0b95200
relation.isAuthorOfPublicationbb0cdccb-8967-47e2-aff8-3e4d4996a57e
relation.isAuthorOfPublication6356cfb4-7ab2-4a3d-b37d-263c86174772
relation.isAuthorOfPublication.latestForDiscoverybb0cdccb-8967-47e2-aff8-3e4d4996a57e
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