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The relationship between severity of disease and vitamin D levels in children with atopic dermatitis

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dc.contributor.authorSu, Ozlem
dc.contributor.authorBEHALI, Anil Gulsel
dc.contributor.authorDEMIR, Aysegul Dogan
dc.contributor.authorOZKAYA, Dilek Biyik
dc.contributor.authorUzuner, SELÇUK
dc.contributor.authorDizman, DİDEM
dc.contributor.authorOnsun, NAHİDE
dc.contributor.institutionauthorSU KÜÇÜK, ÖZLEM
dc.contributor.institutionauthorUZUNER, SELÇUK
dc.contributor.institutionauthorDİZMAN, DİDEM
dc.contributor.institutionauthorONSUN, NAHIDE
dc.date.accessioned2019-10-05T14:51:01Z
dc.date.available2019-10-05T14:51:01Z
dc.date.issued2017-01-01
dc.description.abstractIntroduction: Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder. Vitamin D is a liposoluble vitamin synthesized mainly in the skin. Vitamin D has several effects on the skin. Aim: To assess the serum level of vitamin D in children with AD and determine its relation to AD severity. Material and methods: Sixty patients with AD were enrolled in the study. We evaluated disease severity using the SCORing Atopic Dermatitis (SCORAD) index. The control group consisted of 37 healthy subjects. Results: The mean serum concentration of 25(OH)D3 in patients with AD was not statistically different from control subjects (p = 0.065). The vitamin D level was significantly lower in moderate and severe AD compared with mild AD, and this difference was statistically significant (p = 0.001 and p = 0.004). Vitamin D showed a negative correlation with serum total IgE levels (p = 0.007). There was no significant correlation between total IgE levels and SCORAD scores (p = 0.089). Conclusions: This study suggests that a low serum vitamin D level is inversely associated with severity of AD in children. Vitamin D has not been included in the routine treatment of AD because of the conflicting results of various studies. Thus, there is a need for more detailed and prospective studies.en
dc.identifier
dc.identifier.citationSu O., BEHALI A. G. , DEMIR A. D. , OZKAYA D. B. , Uzuner S., Dizman D., Onsun N., -The relationship between severity of disease and vitamin D levels in children with atopic dermatitis-, POSTEPY DERMATOLOGII I ALERGOLOGII, cilt.34, ss.224-227, 2017
dc.identifier.doi10.5114/pdia.2017.66054
dc.identifier.pubmed28670250
dc.identifier.scopus85020007288
dc.identifier.urihttps://hdl.handle.net/20.500.12645/4865
dc.identifier.wosWOS:000403386700006
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleThe relationship between severity of disease and vitamin D levels in children with atopic dermatitis
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameAMERICAN JOURNAL OF NEURORADIOLOGY
local.avesis.id777fcd79-b41e-4ac8-9086-f73ff49e3556
local.avesis.response4735
local.org.facultyTıp Fakültesi
local.publication.isinternational1
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relation.isAuthorOfPublication5a52edc0-0365-409d-88ce-c6afe0470201
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relation.isAuthorOfPublication.latestForDiscoveryfd8dc121-9bbe-4ee4-a2fd-5e237676169d
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