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Fibromiyalji Sendromu ile Bağırsak Mikrobiyotası Arasındaki İlişkinin Araştırılması

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dc.contributor.authorAlbayrak, Büşra
dc.contributor.authorSüsgün, Seda
dc.contributor.authorKüçükakkaş, Okan
dc.contributor.authorAkbaş, Fahri
dc.contributor.authorYabacı, Ayşegül
dc.contributor.authorÖzçelik, Semra
dc.contributor.institutionauthorSÜSGÜN, SEDA
dc.contributor.institutionauthorKÜÇÜKAKKAŞ, OKAN
dc.contributor.institutionauthorAKBAŞ, FAHRİ
dc.contributor.institutionauthorYABACI TAK, AYŞEGÜL
dc.date.accessioned2020-12-25T20:59:06Z
dc.date.available2020-12-25T20:59:06Z
dc.date.issued2020-12-31T00:00:00Z
dc.description.abstractFibromyalgia syndrome (FMS) is one of the frequent forms of chronic widespread pain, with a reported prevalence of 2% to 4% in the adult population. Nervous system dysfunction is implicated in FMS and neurotransmitters are the targets of a number of drugs approved for fibromyalgia. However exact underlying mechanisms of FMS are unknown yet and multiple hypotheses being suggested. Considering the relation between fibromyalgia and irritable bowel syndrome, altered gut microbiome could be associated with fibromyalgia. Herein, altered gut microbiome levels were investigated in patients with FMS compared to healthy controls. We collected faeces to study the microbiome, from a cohort of 54 patients with FMS and 36 healthy individuals. Extraction of DNA was carried out with commercial kit according to the manufacturer’s recommendations. Samples were compared using 16S rRNA gene amplification with specific primers of Bacteroidetes, Firmicutes, Enterobacteria, Lactobacillus, Streptococcus and Bifidobacterium by the Real-Time PCR instrument. According to our results, Bacteroidetes and Bifidobacteria were increased statistically significant (p<0.05), Firmicutes was decreased (p<0.001) in the patient group. No statistically significant results were found for Enterobacterium, Streptococcus and Lactobacillus (p>0.05). When the relationship between bacteria was evaluated, statistically significant and negative correlation was found between Bacteroidetes and Firmicutes percentage (r =-0.778, p <0.001). A moderately positive correlation was observed between the percentage of Enterobacter and Bifidobacter (r = 0.460, p = 0.005). The results suggest that the gut microbiota may play a role in fibromyalgia.t the gut microbiota may play a role in fibromyalgia. In sum, it is clear that large-scale further research in larger cohorts will be efficient in understanding the relationship of gut microbiome and FMS and evaluating possible treatment options.
dc.identifier.trdizinDOI: https://doi.org/10.5578/mb.20219903
dc.identifier.urihttp://hdl.handle.net/20.500.12645/27810
dc.subjectFibromiyalji sendromu
dc.subjectBacteroidetes
dc.subjectFirmicutes
dc.subjectBifidobacterium
dc.subjectmikrobiyota
dc.titleFibromiyalji Sendromu ile Bağırsak Mikrobiyotası Arasındaki İlişkinin Araştırılması
dc.typeConference Paper
dspace.entity.typePublication
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local.publication.isinternational0
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