Publication:
Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats

Simple item page
dc.contributor.authorEsrefoglu, MUKADDES
dc.contributor.authorAKINCI, Aysin
dc.contributor.authorElbe, Hulya
dc.contributor.authorTAŞLIDERE, ELİF
dc.contributor.authorCetin, Asli
dc.contributor.authorATEŞ, BURHAN
dc.contributor.institutionauthorEŞREFOĞLU, MUKADDES
dc.contributor.institutionauthorTAŞLIDERE, ELİF
dc.date.accessioned2020-10-29T21:54:04Z
dc.date.available2020-10-29T21:54:04Z
dc.date.issued2014-01-01T00:00:00Z
dc.description.abstractIn the present study, we tried to investigate the effects of melatonin, a novel antioxidant and a potent free radical scavenger, in stress-induced cerebral, cerebellar, cardiac, and hepatic oxidative damage using microscopic and biochemical analysis. A total of 32 male Wistar albino rats were divided into control, stress, stress + saline, and stress + melatonin groups. The rats from the stress groups were exposed to high stress conditions of starvation, immobilization, and cold exposure. The rats from the stress + melatonin group received melatonin daily at 20 mg/kg body weight intraperitoneally for 7 days. At the end of the experiment, the brain, cerebellum, heart, and liver were rapidly removed. The main histopathological damage scores (MHDSs) of the stress and stress + saline groups were higher than those of control group for all of the organs. The MHDSs of melatonin-administered group were lower than those of stress and stress + saline groups. The main tissue superoxide dismutase activities of the stress + melatonin group were even higher than those of the control group in the cerebellum and liver, and main tissue catalase activities of the stress + melatonin group were even higher than those of control group in all of the organs. As a conclusion, we found melatonin very effective in reducing stress-induced organ damage by inhibiting lipid peroxidation and supporting the cellular antioxidant defense system.
dc.identifier.citationEsrefoglu M., AKINCI A., Elbe H., TAŞLIDERE E., Cetin A., ATEŞ B., -Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats-, TURKISH JOURNAL OF BIOLOGY, cilt.38, ss.493-501, 2014
dc.identifier.doi10.3906/biy-1401-90
dc.identifier.scopus84901793890
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26463
dc.identifier.urihttps://journals.tubitak.gov.tr/biology/index.htm
dc.identifier.wosWOS:000337274500008
dc.subjectMelatonin
dc.titleMelatonin is effective in reducing stress-induced organ damage in Wistar albino rats
dc.typeArticle
dspace.entity.typePublication
local.avesis.ida225bf5f-4993-4448-b2df-e409ad624eb5
local.publication.isinternational1
relation.isAuthorOfPublicationd0c7c343-3b7d-47ef-a2a7-5169234110eb
relation.isAuthorOfPublication1bcd2ccf-c1aa-4999-a863-1d634b1c7fe6
relation.isAuthorOfPublication.latestForDiscovery1bcd2ccf-c1aa-4999-a863-1d634b1c7fe6
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
biy-38-4-8-1401-90.pdf
Size:
4.27 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Yayınlar - Eserler