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Human paraoxonase-1 activity in children with acute bronchiolitis Akut bronşiolitli çocuklarda human paraoksonaz-1 aktivitesi

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dc.contributor.authorERENBERK, UFUK
dc.contributor.authorKahraman, Feyza Ustabaş
dc.contributor.authorÖzkaya, Emin
dc.contributor.authorNURSOY, MUSTAFA ATİLLA
dc.contributor.authorDemir, Ayşegül Doğan
dc.contributor.authorTÜREL, Özden
dc.contributor.institutionauthorERENBERK, UFUK
dc.contributor.institutionauthorÖZKAYA, EMİN
dc.contributor.institutionauthorNURSOY, MUSTAFA ATİLLA
dc.contributor.institutionauthorTÜREL, ÖZDEN
dc.date.accessioned2021-01-18T21:00:03Z
dc.date.available2021-01-18T21:00:03Z
dc.date.issued2020-01-01T00:00:00Z
dc.description.abstract© 2020, Galenos. All rights reserved.INTRODUCTION: Human paraoxonase-1 (PON1) is one of the endogenous antioxidant molecules working against oxidative stress. We aimed to investigate serum PON1 activity in children with acute bronchiolitis. MATERIALS and METHODS: A total of 29 children aged between 3-21 months with acute bronchiolitis and 35 age-matched healthy controls were included in the study. Bronchiolitis patients were further classified as mild (65%) and moderate (35%). Paraoxonase and arylesterase activities of PON1 were compared between patients with acute bronchiolitis and the control group. RESULTS: Paraoxonase activity of children with acute bronchiolitis was lower than healthy controls but the difference was not significant (127.53 ± 64.17 U/L versus 153.95 ± 74.40 U/L) (p=0.13). Arylesterase activity was significantly decreased in children with mild and moderate bronchiolitis in comparison to the control group (142.43± 56.60 kU/L and 103.70± 26.03 kU/L versus 201.09± 57.26 kU/L) (p<0.001). CONCLUSIONS: Serum PON1 activity was lower in children with acute bronchiolitis compared to controls. Increasing antioxidant capacity may be an effective means of therapy in viral induced lung disease.
dc.identifier.citationERENBERK U., Kahraman F. U. , Özkaya E., NURSOY M. A. , Demir A. D. , TÜREL Ö., -Human paraoxonase-1 activity in children with acute bronchiolitis Akut bronşiolitli çocuklarda human paraoksonaz-1 aktivitesi-, Guncel Pediatri, cilt.18, ss.336-345, 2020
dc.identifier.doi10.32941/pediatri.841417
dc.identifier.scopus85098010747
dc.identifier.urihttp://hdl.handle.net/20.500.12645/27981
dc.titleHuman paraoxonase-1 activity in children with acute bronchiolitis Akut bronşiolitli çocuklarda human paraoksonaz-1 aktivitesi
dc.typeArticle
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local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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