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Effects of chitosan on healing and strength of colonic anastomosis in rats

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dc.contributor.authorCITGEZ, B
dc.contributor.authorCENGIZ, AN
dc.contributor.authorAKGUN, I
dc.contributor.authorULUDAG, M
dc.contributor.authorYETKIN, G
dc.contributor.authorBAHAT, N
dc.contributor.authorOZCAN, O
dc.contributor.authorPOLAT, N
dc.contributor.authorAkcakaya, ADEM
dc.contributor.authorKARATEPE, O
dc.contributor.institutionauthorAKÇAKAYA, ADEM
dc.date.accessioned2019-10-05T15:03:53Z
dc.date.available2019-10-05T15:03:53Z
dc.date.issued2012-10-01
dc.description.abstractPURPOSE: To investigate whether chitosan application over colonic anastomosis line, provide reinforcement, and subsequently improve anastomotic healing. METHODS: Forty eight Wistar albino female rats were used and were randomly divided into four groups, 12 rats in each: The control groups (1 and 3) received no further treatment. The experimental groups (2 and 4) received chitosan application over the colonic anastomosis. After sacrifying rats at the end of the experiment (either on day three or on day seven, depending on the group), colonic bursting pressure, a hihydroxyproline level and histopathologic characteristics of the perianastomotic tissue were examined. RESULTS: At three days, chitosan and control groups had similar values for histopathologically. On day seven, chitosan group had significantly higher mean score of collagenization (p=0.007) and a significantly higher bursting pressure (p=0.038). CONCLUSION: Our study emphasizes the positive effect of chitosan in the process of collagenation in colonic anastomosis healing.
dc.identifier10.1016/j.brainresbull.2010.04.013
dc.identifier.citationhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001000007
dc.identifier.citationCITGEZ B., CENGIZ A., AKGUN I., ULUDAG M., YETKIN G., BAHAT N., OZCAN O., POLAT N., Akcakaya A., KARATEPE O., -Effects of chitosan on healing and strength of colonic anastomosis in rats.-, Acta cirurgica brasileira, cilt.27, ss.707-12, 2012
dc.identifier.pubmed
dc.identifier.urihttps://hdl.handle.net/20.500.12645/5357
dc.identifier.urihttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001000007
dc.identifier.wosWOS:000309425300007
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGastrointestinal anastomoses
dc.titleEffects of chitosan on healing and strength of colonic anastomosis in rats
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameBRAIN RESEARCH BULLETIN
local.avesis.id83b533dd-d3fc-4609-8a44-0f197d2a6938
local.avesis.response5227
relation.isAuthorOfPublication3a721c5d-4553-489c-99f3-7bf02f7a09f0
relation.isAuthorOfPublication.latestForDiscovery3a721c5d-4553-489c-99f3-7bf02f7a09f0
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